AI Article Synopsis
- The study measured levels of maternal serum alpha-fetoprotein (MSAFP), human chorionic gonadotropin (hCG), and unconjugated oestriol (uE3) in serum samples from pregnancies affected by neural-tube defects (NTDs) and ventral wall defects (VWD), comparing them to a large group of unaffected pregnancies.
- Results showed that levels of AFP and uE3 were significantly different in pregnancies with open NTDs, while hCG levels did not show any significant differences compared to controls.
- The exact reasons for the altered uE3 levels in pregnancies with fetal NTDs remain unclear, indicating a need for further research.
Article Abstract
Maternal serum alpha-fetoprotein (MSAFP), human chorionic gonadotropin (hCG) and unconjugated oestriol (uE3) concentrations were measured in maternal serum samples from 21 pregnancies with neural-tube defects, 4 pregnancies with ventral wall defects (VWD) and 1662 unaffected pregnancies in women. These congenital malformations were confirmed by ultrasound scanning. The mean multiplate of the median (MoM) for AFP and uE3 was significantly different from the control values in cases of open NTD (AFP median MoM = 5.95, p < 0.001, uE3 median MoM = 0.2, p < 0.001), while hCG values did not differ from those of matched controls (hCG median MoM = 0.9). The biological basis of altered levels of uE3 in pregnancies with fetal NTDs is unclear.
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