The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM(197). Utilizing antigen-processing cells and a CRM(197)-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM(197). Unconjugated CRM(197) and serotype conjugates 14 and 18C were processed more efficiently.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC161992 | PMC |
| http://dx.doi.org/10.1128/IAI.71.7.4186-4189.2003 | DOI Listing |
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