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Different strains of Toxoplasma gondii induce different cytokine responses in CBA/Ca mice. | LitMetric

Different strains of Toxoplasma gondii induce different cytokine responses in CBA/Ca mice.

Infect Immun

Research Institute, Palo Alto Medical Foundation, Palo Alto, California 94301, USA.

Published: July 2003

To investigate the role that cytokines may have in the development of toxoplasmic encephalitis (TE), the levels of gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin-12 (IL-12 ]p40[), IL-10, IL-6, IL-4, and IL-2 in serum were examined in CBA/Ca mice infected with a type II strain (ME49 or FORT) of Toxoplasma gondii. These strains caused severe (ME49) or mild (FORT) TE in CBA/Ca mice. From weeks 1 to 8 of infection, the levels of IL-6, IL-10, IL-12, IFN-gamma, and TNF-alpha in serum were significantly higher in the ME49-infected mice than in the FORT-infected mice, suggesting a role for these cytokines in the severity of TE in CBA/Ca mice. Since the ME49 and FORT strains are of the same type, our results suggest a role for the parasite in the development of severe TE through the increased production of proinflammatory cytokines and indicate that not all type II strains cause TE.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162004PMC
http://dx.doi.org/10.1128/IAI.71.7.4171-4174.2003DOI Listing

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