This report describes three cases in which the addition of recombinant HCG to urinary HCG to trigger ovulation in IVF improved oocyte recovery in patients with a history of scant oocyte yield in previous cycles.
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Objective: We aimed to compare highly purified human menopausal gonadotropin (hp-hMG) and recombinant follicle stimulating hormone (rFSH) in short antagonist in vitro fertilization (IVF) cycles of patients with poor ovarian reserve (POR). Limited research exists on this comparison in short antagonist cycles for this patient group.
Materials And Methods: This retrospective cohort study involved 165 POR patients aged 18-45 years who underwent IVF between 2018 and 2022.
Efficacy of uterine flushing with human chorionic gonadotropin (hCG) on pregnancy rates in primary unexplained infertility: a randomized controlled trial.
Eur J Med Res
December 2024
Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: There are limited and controversial findings concerning ovulation induction using intrauterine and intramuscular human chorionic gonadotropin (hCG) injection compared to intramuscular hCG alone. The study aimed to examine the impact of intrauterine hCG injection, which is used to induce ovulation, on the efficacy of the intrauterine insemination (IUI) technique in patients with unexplained infertility.
Methods: A randomized controlled clinical trial was conducted involving 80 subjects with unexplained primary infertility at the infertility clinic of Al-Zahra Hospital in northwest Iran.
Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates.
Adv Mater
December 2024
Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Article Synopsis
- Follicular tracking is usually done with ultrasound, but it has limited resolution; a new high-resolution imaging technique using near-infrared II (NIR-II) luminescence imaging has been developed for better visualization of ovarian follicles.
- This approach utilizes an FDA-approved contrast agent, indocyanine green (ICG) conjugated with hCG, allowing targeted monitoring of early follicles and avoiding damage from other imaging methods like CT scans.
- Results indicate that the NIR-II imaging can accurately identify follicles as small as 50 µm and also effectively detect ovarian tumors and micro-metastatic lesions, presenting a promising tool for infertility assessment and surgical guidance.
Ovarian stimulation of Nelore calves and prepubertal heifers with a long-acting recombinant human FSH (corifollitropin-alpha) and subsequent ovum pick-up and in vitro embryo production outcomes.
Theriogenology
March 2025
Universidade de Brasília, Brasília, DF, 70910-900, Brazil; Embrapa Recursos Genéticos e Biotecnologia, Brasília, DF, 70770-901, Brazil. Electronic address:
The aim of this study was to evaluate the use of a long-acting recombinant human FSH (rhFSH, corifollitropin-alpha) to induce ovarian stimulation in Nelore breed (Bos indicus) calves and prepubertal heifers prior to ovum pick-up (OPU) for in vitro embryo production (IVEP). In Experiment 1, a dose-response trial was performed to determine the optimal dose of rhFSH, which was determined to be 10 μg. In Experiment 2, 6-7 mo old calves were randomly allocated to receive rhFSH either via sc (n = 5) or im (n = 5).
View Article and Find Full Text PDFThe impact of oral multinutrient supplementation on in vitro fertilisation or intracytoplasmic sperm injection outcomes: A prospective controlled study.
Med J Malaysia
November 2024
UMFertility, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
Introduction: Micronutrients influence female fertility, thus adequate levels are important for oocyte quality, maturation, fertilisation and implantation. This study prospectively evaluated the impact of oral multinutrient supplementation on fertility outcomes in In vitro fertilisation or Intracytoplasmic sperm injection (IVF/ICSI).
Materials And Methods: This was a pilot study of N=50 women, who were planning for IVF treatment in University Malaya Medical Centre, Kuala Lumpur, Malaysia from July to December 2023.
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