AI Article Synopsis
- Hyperhomocysteinemia is identified as a significant risk factor for early myocardial infarction, especially in men aged 45 and younger.
- A study found that patients with early myocardial infarction had notably higher plasma homocysteine levels compared to healthy controls, indicating a strong association with this condition.
- The research concluded that hyperhomocysteinemia plays a crucial role in increasing the risk of early myocardial infarction and is linked to factors involved in the coagulation process.
Article Abstract
Introduction: Hyperhomocysteinemia is a coronary risk factor, but its pathophysiologic mechanism remains unclear.
Materials And Methods: The importance of hyperhomocysteinemia in the pathogenesis of early myocardial infarction, was determined in case-control study of 127 men with a first early myocardial infarction
Results: Homocysteine concentrations were higher in patients with early myocardial infarction than in controls (11.2+/-5.3 and 8.3+/-5.0 micromol/l, respectively, P<0.001). Hyperhomocysteinemia was associated with early myocardial infarction (odds ratio=2.22, P<0.001) by multivariate logistic regression analysis. Tissue factor, antithrombin, plasminogen, tissue plasminogen activator, plasminogen activator inhibitor-I, lipoprotein(a), diabetes, and smoking also had associations. In a stepwise logistic regression analysis, hyperhomocysteinemia was the strongest predictor of early myocardial infarction (R(2)=0.19, P<0.001). Hyperhomocysteinemia also had positive correlations with tissue factor (rho=0.26, P=0.009), tissue factor pathway inhibitor (rho=0.23, P=0.020), and tissue plasminogen activator (rho=0.25, P=0.011) in patients with early myocardial infarction, but not in controls.
Conclusions: Hyperhomocysteinemia is an independent risk factor for early myocardial infarction, and is associated with a hypercoagulable state mediated by the extrinsic coagulation cascade.
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| http://dx.doi.org/10.1016/s0049-3848(03)00242-1 | DOI Listing |
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