Strain Tü 6239 was isolated from a soil sample collected in Brazil and determined as a new species of the genus Streptomyces. In the course of our HPLC-diode array screening program three metabolites were detected in the culture filtrate and mycelium extracts of strain Tü 6239. They were characterised as members of the macrolactam group, the new compound ripromycin (1), the previously described ikarugamycin (2) and a new derivative of it, ikarugamycin epoxide (3). They show antibiotic activities against gram-positive bacteria and cytostatic effects to various human tumor cell lines.
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Radiology
October 2020
From the Departments of Physics (S.T., G.D.C.), Biomedical Engineering (W.J.G., J.P.M., G.W.M.), Radiology and Medical Imaging (J.P.M., J.F.M., E.E.d.L., A.M.R., G.W.M.), and Medicine (Y.M.S.), University of Virginia, Box 801339, Charlottesville, VA 22908; Department of Radiology, University of Missouri, Columbia, Mo (T.A.A.); and Department of Science and Engineering, University of Nottingham, Ningbo, China (C.W.).
Background Apparent diffusion coefficient (ADC) maps of inhaled hyperpolarized gases have shown promise in the characterization of emphysema in patients with chronic obstructive pulmonary disease (COPD), yet an easily interpreted quantitative metric beyond mean and standard deviation has not been established. Purpose To introduce a quantitative framework with which to characterize emphysema burden based on hyperpolarized helium 3 (He) and xenon 129 (Xe) ADC maps and compare its diagnostic performance with CT-based emphysema metrics and pulmonary function tests (PFTs). Materials and Methods Twenty-seven patients with mild, moderate, or severe COPD and 13 age-matched healthy control subjects participated in this retrospective study.
View Article and Find Full Text PDFEffects of intranasal corticosteroids on adrenal, bone, and blood markers of systemic activity in allergic rhinitis.
J Allergy Clin Immunol
October 1998
Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital & Medical School, University of Dundee, Scotland.
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