Objective: Pertussis is commonly regarded as a disease of children but a number of clinical studies show that quite often it occurs in older children and adults, too. The purpose of the present study was to determine the prevalence of Bordetella pertussis infection in an Italian population of adults with persistent non-productive cough.
Methods: Pertussis was considered in the differential diagnosis of a prospective case series of 180 adult patients with unexplained non-productive chronic cough. To diagnose pertussis, nasopharyngeal swabs for culture were obtained and antibodies IgA and IgG against multiple B. pertussis whole body antigens were counted by enzyme-linked immunosorbent assay in a single serum sample.
Results: The prevalence of pertussis with unexplained persistent cough was 10% of the cases. Significantly high amounts of specific IgA, that is at least 2 standard deviations greater than the geometric mean of the control group, were observed in 19 subjects. None of these patients had the typical symptoms of pertussis.
Conclusions: Pertussis is quite a common cause of persistent cough in adults and should always be considered in differential diagnosis. Pertussis cases can easily be diagnosed by demonstrating IgA antibodies high titers in single serum samples, compared with those of population controls.
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Vaccines (Basel)
January 2025
South Eastern Sydney Public Health Unit, Sydney, NSW 2031, Australia.
School-based immunization programs are crucial for equitable vaccine coverage, yet their success depends on parental consent processes. This study investigates patterns of vaccine decision-making within Australia's school-based immunization program, specifically focusing on human papillomavirus (HPV) and diphtheria-tetanus-pertussis (dTpa) vaccines offered free to adolescents aged 12-13. This qualitative study was conducted in the South Eastern Sydney Local Health District (2022-2023).
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January 2025
Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, Singapore 119074, Singapore.
Pertussis, or whooping cough, is a highly contagious respiratory infection caused by the Gram-negative bacterium . Although traditionally associated with children, pertussis is increasingly prevalent among adults, particularly those with comorbidities or weakened immune systems, where it can lead to severe complications. Diagnosing pertussis in adults can be challenging due to its nonspecific symptoms, underreporting, and the limited sensitivity of available diagnostic tests.
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December 2024
World Health Organization, Regional Office for Africa, Brazzaville P.O. Box 06, Congo.
: The Addis Declaration on Immunization (ADI) is a historic pledge aiming at increasing political will to achieve universal access to immunization services and includes ten commitments to shape the future of immunization in Africa. : To analyze African countries' performance in achieving the fourth ADI commitment, a cross-sectional retrospective study was conducted including the 54 African Member States of the World Health Organization (WHO) out of 55 African Union (AU) Member States. The fourth ADI commitment aims at increasing the effectiveness and efficiency of immunization delivery systems and has four performance indicators.
View Article and Find Full Text PDFZhonghua Yu Fang Yi Xue Za Zhi
January 2025
Immunization Program Institute of Shaanxi Provincial Center for Disease Control and Prevention, Xi'an 710054, China.
To investigate the safety of the tetravalent meningococcal conjugate vaccine (MPCV-ACYW) in combination with the inactivated poliomyelitis (IPV) vaccine and diphtheria-tetanus-acellular pertussis (DTaP) vaccine for infants aged 3-5 months and provide real-world evidence for the immunization strategy of vaccine combination. From June to October 2023, a total of 600 3-month-old infants were selected and divided into three groups: control group, mono-vaccination group and combined vaccination group. They were simultaneously or individually vaccinated with MPCV-ACYW, IPV and DTaP vaccines at 3, 4, and 5 months of age, respectively.
View Article and Find Full Text PDFAm J Public Health
January 2025
Stacey L. Rowe is with the School of Nursing and Health Professions, University of San Francisco, San Francisco, CA. Sheena G. Sullivan is with the School of Clinical Sciences, Monash University, Melbourne, Australia. Flor M. Munoz is with the Department of Pediatrics, Baylor College of Medicine, Houston, TX. Matthew M. Coates and Onyebuchi A. Arah are with the Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles. Annette K. Regan is with the Department of Research and Evaluation, Kaiser Permanente Research, Pasadena, CA.
To estimate maternal COVID-19, influenza, and pertussis vaccine uptake during pregnancy by insurance type and identify factors characterizing those vaccinated and unvaccinated. We conducted a US cohort study of pregnant individuals (for pregnancies ending December 11, 2020-September 30, 2022) using insurance claims data. We calculated vaccination probability using Kaplan-Meier methods and identified factors associated with vaccination through binomial regression with inverse probability weights.
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