On the occasion of the 150th anniversary of the death of Franz von Paula Gruithuisen, the authors present his life and work. His most significant work in the fields of urology and lithotrity is examined, with special emphasis on the development of the latter field. He published his epoch-making historic study in 1813 in the Journal of Medicine and Surgery (Medicinisch-Chirurgische Zeitung). Franz von Paula Gruithuisen, the Bavarian physician and astronomer, led the way in the field of lithotrity. He developed crucial ideas on how to remove bladder stones transurethrally in a way that was safer and less likely to cause death. His instruments can be regarded as the model on which subsequent devices are based. Gruithuisen's influence on European medical scientists and, in particular, his rivalry with Jean Civiale are discussed.
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Cortex
November 2024
Neurologische Klinik und Poliklinik, LMU Klinikum, LMU München, Munich, Germany. Electronic address:
A case of brain injury with a transient syndrome of mainly disinhibited behaviour (Franz Binz) was the subject of the 1888 medical dissertation of Leonore Welt (∗1859 Chernivtsi, Ukraine; †1944 Geneva, Switzerland) which came to be discussed quite controversially. Although Binz was never fully forgotten, the similar "American crow-bar case" (Phineas Gage) attracted more interest. Welt's study, in contrast, provides not only well-illustrated neuropathological findings but also more detailed clinical data.
View Article and Find Full Text PDFJ Hematol Oncol
December 2024
Experimentelle Unfallchirurgie (ForMED), Justus-Liebig-Universität Gießen, Aulweg 128, 35392, Gießen, Germany.
Background: Accumulation of malignant plasma cells in the bone marrow causes lytic bone lesions in 80% of multiple myeloma patients. Frequently fracturing, they are challenging to treat surgically. Myeloma cells surviving treatment in the presumably protective environment of bone lesions impede their healing by continued impact on bone turnover and can explain regular progression of patients without detectable minimal residual disease (MRD).
View Article and Find Full Text PDFDermatologie (Heidelb)
December 2024
Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
HNO
December 2024
Klinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Deutschland.
Ultrasound is today an essential element of otorhinolaryngology. During the course of (technical) development, fracture sonography has also gained increasing clinical and scientific interest. Sonography can already be used today as the imaging method of choice for isolated suspected fractures of the nasal or zygomatic bone.
View Article and Find Full Text PDFiScience
November 2024
Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Straße 8 D-55131 Mainz, Germany.
Statistical interaction analyses with biomarkers of pathology on cognitive outcome have been put forward to investigate neurobiological surrogates of cognitive reserve in Alzheimer's disease (AD). However, as these potential surrogates are likely affected by neurodegeneration during the course of AD, their joint alteration with biomarkers of pathology and cognitive outcome during disease progression may introduce misinterpretable interaction effects in cross-sectional studies. To demonstrate this, we conducted interaction analyses on synthetic data from a mathematical model of the AD biomarker cascade.
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