Combinations of small, gaseous hydrocarbons and sizable aromatics, e.g. methane and anthracene, are directly observed in a cylindrical capsule by NMR.
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http://dx.doi.org/10.1039/b300996c | DOI Listing |
Int J Pharm
January 2025
Centre for Pharmacy, Department of Clinical Science, University of Bergen, Norway. Electronic address:
The backbone of induction therapy in acute myeloid leukaemia (AML) is to use an anthracycline in combination with cytarabine. Despite recent advances in AML therapy, this treatment remains the standard, and it has been largely unchanged for decades. There are few curative options for patients unfit for this treatment.
View Article and Find Full Text PDFJ Control Release
November 2024
Department of Biomedical Sciences, School of Infection, Inflammation, & Immunology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address:
The process of microencapsulation and the development of microparticle-based drug formulations have gained increased pharmaceutical interest, particularly for drug delivery and bacterial-encapsulation purposes for probiotic delivery. Existing studies have examined microcomposite (MC) responses to gastrointestinal (GI) conditions with the aim of controlling disintegration, and thus release, across the small and large bowel. However, the delivery of MCs which remain intact, without degrading, could act as bacterial growth scaffolds or materials providing a prebiotic support, conferring potentially beneficial GI health properties.
View Article and Find Full Text PDFNat Mater
December 2024
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Nanoparticles are promising for drug delivery applications, with several clinically approved products. However, attaining high nanoparticle accumulation in solid tumours remains challenging. Here we show that tumour cell-derived small extracellular vesicles (sEVs) block nanoparticle delivery to tumours, unveiling another barrier to nanoparticle-based tumour therapy.
View Article and Find Full Text PDFCrit Rev Food Sci Nutr
August 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, China.
Algal oil rich in docosahexaenoic acid is easily oxidized and degraded to produce volatile short-chain compounds, leading to the deterioration of product flavor. Currently, the emulsion delivery of algal oil provides a promising approach to minimize oxidative deterioration and conceal its off-flavor. However, algal oil emulsions would also experience unanticipated oxidation as a result of the large specific surface area between the aqueous phase and the oil phase.
View Article and Find Full Text PDFMethods Mol Biol
July 2024
Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA, Australia.
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