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O-GlcNAcylation dictates pyroptosis.
Front Immunol
January 2025
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Article Synopsis
- O-GlcNAcylation is a modification that adds a sugar molecule, N-acetylglucosamine, to specific amino acids, influencing signaling pathways important for pyroptosis, a form of cell death.
- Enhancing O-GlcNAcylation of the protein GSDMD is suggested as a key strategy for improving blood flow issues in sepsis, while GSDME's role in macrophage pyroptosis is linked to high glucose levels in periodontitis.
- The review discusses O-GlcNAcylation's impact on the NLRP3 inflammasome and other regulators, highlighting its potential as a therapeutic target for diseases like sepsis and osteoarthritis by managing inflammation.
[Chondroprotective therapy and adjuvant support for patients with chronic lower back pain].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
International University of Restorative Medicine, Moscow, Russia.
The trend of an annual increase in the detection of new cases of osteoarthritis (OA) and an increase in the number of patients with chronic lower back pain (LBP) calls for the search for new drugs and pharmaconutraceuticals with anti-inflammatory and chondroprotective properties. In 2019, approaches to the treatment of pain in OA significantly changed. In international and Russian clinical guidelines (CG), pharmaconutraceutical chondroitin sulfate (CS) and glucosamine sulfate (GS) are recommended for OA of different localization as a basic therapy.
View Article and Find Full Text PDF[Mechanism of Astragali Radix in treatment of knee osteoarthritis based on GLP-1/GLP-1R axis].
Zhongguo Zhong Yao Za Zhi
November 2024
College of Basic Medical Sciences, Shanxi University of Chinese Medicine Jinzhong 030600, China.
This study aims to observe the effects of different doses of Astragali Radix on the expression of glucagon(GLP-1) in se-rum and glucagon receptor(GLP-1R) in cartilage tissue in rats with knee osteoarthritis(KOA), explore the effect of Astragali Radix on the inflammation and apoptosis of KOA by regulating GLP-1/GLP-1R signaling axis, and investigate the mechanism of its action in alleviating KOA. Forty-eight male SD rats were randomly divided into six groups: blank group, model group, low-, medium-, and high-dose Astragali Radix groups(3.125, 6.
View Article and Find Full Text PDFAFY02 (LR-AFY02) is a newly discovered strain isolated and identified from naturally fermented yogurt in Xinjiang, China. This research aims to investigate the mechanism of action of LR-AFY02 in mice with acute gouty arthritis. We examined the degree of foot swelling, pain threshold, blood biochemical indicators, histopathological changes, and mRNA expression.
View Article and Find Full Text PDFIn mice with acute gouty arthritis, this study intends to examine the mechanism of action of AKK PROBIO. We developed a mouse model of acute gouty arthritis using sodium urate. The efficiency and mechanism of AKK PROBIO in preventing acute gouty arthritis in mice were then determined by examining the degree of foot swelling, pain threshold, blood biochemical indicators, histological alterations, and messenger RNA (mRNA) expression changes.
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