This clinical report describes an unusual situation of nasal discharge that was initially considered to be caused by a leaking obturator prosthesis in a partially repaired cleft palate patient. Ultimately, the diagnosis was rhinorrhea induced by the loading of dental implants that supported the obturator. The differential diagnoses of nasal irritation, blocking of nasal drainage posterior or anterior through a premaxillary defect, vasomotor rhinitis, and gustatory rhinorrhea are presented and discussed, as well as the measures taken to reach the final diagnosis.
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http://dx.doi.org/10.1016/s0022-3913(03)00078-7 | DOI Listing |
Pharmaceuticals (Basel)
December 2024
Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Late-onset Alzheimer's disease (LOAD) is a chronic, multifactorial, and progressive neurodegenerative disease that associates with aging and is highly prevalent in our older population (≥65 years of age). This hypothesis generating this narrative review will examine the important role for the use of sodium thiosulfate (STS) as a possible multi-targeting treatment option for LOAD. Sulfur is widely available in our environment and is responsible for forming organosulfur compounds that are known to be associated with a wide range of biological activities in the brain.
View Article and Find Full Text PDFBMJ Case Rep
December 2024
Otorhinolaryngology, IPO Coimbra, Coimbra, Portugal.
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor receptors, has become a widely used treatment for various types of cancer, including metastatic colorectal cancer. However, while the benefits of bevacizumab in improving survival outcomes have been well-documented, it is important to consider the potential adverse effects associated with this therapy. We report a case of a male patient in his 50s with a history of metastatic colorectal cancer who began a regimen of bevacizumab in combination with chemotherapy.
View Article and Find Full Text PDFFront Allergy
November 2024
UMass Memorial Medical Center, Worcester, MA, United States.
A 47-year-old woman presents to our clinic with a chief complaint of rhinorrhea; she had chronic hypertension managed with four antihypertensive drugs, including an ACE inhibitor. While dry cough is a well-known side effect associated with ACE inhibitors, this case highlights a common chief complaint yet less recognized side effect of ACE inhibitors and further emphasizes the idea that overall, angiotensin receptor blockers may be a better drug of choice in hypertension due to their favorable side effect profile.
View Article and Find Full Text PDFCurr Med Res Opin
December 2024
Medical Department, UPSA, Rueil-Malmaison, France.
The common cold is the most frequent upper respiratory viral infection. Although benign, it represents a high socioeconomic burden. Many over-the-counter drugs are available to manage the symptoms of this condition, with antihistamines and vasoconstrictors being the most widely used.
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