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Transient upregulation of procaspase-3 during oligodendrocyte fate decisions.
J Neurosci
January 2025
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
Oligodendrocytes are generated throughout life and in neurodegenerative conditions from brain resident oligodendrocyte precursor cells (OPCs). The transition from OPC to oligodendrocyte involves a complex cascade of molecular and morphological states that position the cell to make a fate decision to integrate as a myelinating oligodendrocyte or die through apoptosis. Oligodendrocyte maturation impacts the cell death mechanisms that occur in degenerative conditions, but it is unclear if and how the cell death machinery changes as OPCs transition into oligodendrocytes.
View Article and Find Full Text PDFDying matters in the emergency department.
Emerg Med J
December 2024
Emergency Department, Queen's Medical Centre, Nottingham, UK
Speaking Truthfully about Provider-Assisted Death.
Hastings Cent Rep
November 2024
Presbyterian Living, Endeavor Health System.
This letter responds to the essay "Language Matters: The Semantics and Politics of 'Assisted Dying,'" by Anna M. Elsner, Charlotte E. Frank, Marc Keller, Jordan O.
View Article and Find Full Text PDFHow bereaved families conceptualise good care and communication in intensive care in South Australia.
BMC Health Serv Res
December 2024
Intensive Care Unit, Royal Adelaide Hospital, Adelaide, Australia.
Since 2018, DonateLife South Australia and the Royal Adelaide Hospital (RAH) have collaborated to deliver routine family follow-up after bereavement in the intensive care unit (ICU). This follow-up includes a telephone interview that invites bereaved family members to comment on the quality of care and communication experienced in the ICU. To identify bereaved families' experiences, including how they conceptualise good care and communication in intensive care, an analysis was conducted on all qualitative data collected during 118 interviews completed between 1 February 2018 and 30 May 2019.
View Article and Find Full Text PDFThe Support Needs of Patients Requesting Medical Aid in Dying and Their Relatives: A Qualitative Study Using Semi-Structured Interviews and Written Narratives.
Int J Public Health
December 2024
End-of-Life Care Research Group, Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel, Brussels, Belgium.
Objectives: To explore the support needs that patients and relatives experience throughout their medical aid in dying (MAID) trajectories.
Methods: A qualitative study in Belgium in 2022 using 1) semi-structured interviews with and personal written narratives of patients requesting MAID and 2) semi-structured interviews with relatives of patients requesting MAID. We performed a qualitative content analysis.
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