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Use of HLDF-6 peptide for correction of disturbances in the endogenous opioid system in offspring of morphine-tolerant animals. | LitMetric
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Use of HLDF-6 peptide for correction of disturbances in the endogenous opioid system in offspring of morphine-tolerant animals.

S V Litvinova I A Kostanyan V V Aristova A L Kalyuzhnyi V V Shul'govskii N N Terebilina L F Panchenko

Bull Exp Biol Med

Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University.

Published: February 2003

We studied the effect of bioactive peptide HLDF-6 on functional activity of the endogenous antinociceptive system in the offspring of morphine-tolerant animals. Disturbances in this system included changes in the thermonociceptive threshold and enkephalinase A activity in various brain structures. The peptide acted as a potent regulator of the homeostasis in systems responsible for the synthesis and catabolism of endogenous opioids. HLDF-6 effectively corrected disorders of the endogenous antinociceptive system.

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http://dx.doi.org/10.1023/a:1023807512200DOI Listing

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