Incubation of hippocampal slices with antibodies to morphine did not change the total excitatory postsynaptic potential of mossy fibers, but markedly facilitated long-term posttetanic potentiation. Culturing of the organotypic hippocampal culture in the presence of 10 microM morphine increased the total excitatory postsynaptic potential of mossy fibers and reduced the probability of long-term posttetanic potentiation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1023/a:1023895109474 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Involvement of CXCL12/CXCR4 in CB2 receptor agonist-attenuated morphine tolerance in Walker 256 tumor-bearing rats with cancer pain.
Eur J Med Res
December 2024
Department of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
While low-dose cannabinoid 2 (CB2) receptor agonists attenuate morphine tolerance in cancer pain models, chemokine ligand 12 (CXCL12)/chemokine receptor 4 (CXCR4) expression induces morphine tolerance. Whether CB2 receptor agonists attenuate morphine tolerance by modulating CXCL12/CXCR4 signaling or whether CXCL12/CXCR4 signaling affects the mu opioid receptor (MOR) in the development of morphine tolerance in cancer pain remains unclear. In this study, we investigated the attenuation of morphine tolerance by a non-analgesic dose of the CB2 receptor agonist AM1241, focusing specifically on the modulation of CXCL12/CXCR4 signaling and its effect on the MOR.
View Article and Find Full Text PDFMorphine treatment restricts response to immunotherapy in oral squamous cell carcinoma.
J Immunother Cancer
November 2024
Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Background: Immune checkpoint inhibitors (ICIs) are becoming the standard of care for recurrent and metastatic cancer. Opioids, the primary treatment for cancer-related pain, are immunosuppressive raising concerns about their potential to interfere with the efficacy of ICIs. We hypothesize that exogenous opioids given for analgesia suppress antitumor immunity via T cell-mediated mu opioid receptor 1 (OPRM1) signaling.
View Article and Find Full Text PDFNew insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system.
Pharmacol Res
November 2024
Department of Neuroscience, Psychology, DrugResearch and Child Health - NEUROFARBA - Section of Pharmacology andToxicology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.
Article Synopsis
- Growing evidence shows that opioid analgesics, like morphine, can affect blood vessel formation (angiogenesis), which is linked to pain.
- The study tested the effects of N-palmitoylethanolamine (PEA) and the anti-VEGF-A drug bevacizumab on morphine tolerance and pain relief, finding that PEA delays tolerance and enhances pain relief by reducing VEGF-A levels in the nervous system.
- Both PEA and bevacizumab, when used with morphine, not only improved pain management but also decreased the expression of pain-related genes, suggesting a potential new approach to pain treatment that targets angiogenesis.
Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA B cells.
Gut Microbes
October 2024
Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, USA.
IgA binding dictates the composition of the intestinal microbiome and reflects dysbiotic states during chronic disease. Both pathogenic and commensal bacteria differentially bind to IgA with varying outcomes. Little is known regarding IgA dynamics immediately following microbial dysbiosis.
View Article and Find Full Text PDFAn easily fabricated nanoporous Au membrane in drug detection with reusable functionality and high SERS performance.
Mikrochim Acta
October 2024
School of Electronic Engineering, Guangxi University of Science and Technology, No.2, Wenchang Road, Liuzhou City, 545006, Guangxi, China.
Article Synopsis
- A method using Surface Enhanced Raman Spectroscopy (SERS) allows for the detection of methamphetamine, ketamine, and morphine by employing a specially prepared nanoporous gold membrane as a substrate.
- The AuNPM substrate exhibited a low limit of detection (LOD) and was optimized using rhodamine 6G as a test analyte.
- The approach involves a competitive immunoassay where drug-specific antigens on the substrate bind to corresponding antibodies, allowing for the qualitative and quantitative identification of the drugs based on changes in SERS intensity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!