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Will artificial intelligence be, one day, powerful enough to obviate the need of randomized clinical trials?
Hell J Nucl Med
January 2024
Formerly, Melanoma Unit, Charing Cross Hospital, London UK.
Artificial Intelligence (AI) currently occupies the headlines in the media as well as the medical press, with messages of its emerging unlimited potential, but also tales of doom and gloom predicting risks for the extinction of humanity! One such headline in the London TIMES of 6 June 2023 reads: - "Two years to save the world, says AI adviser". To the uninformed, AI is nothing more than the processing of a colossal amount of data with lightning speed, now achievable with the latest spectacular developments in computing. However, could such power be harnessed to accurately predict the therapeutic potential of a new treatment emerging from Phase I, or Phase II trials, without the need to proceed to Phase III randomised, at times placebo controlled, trials? The deontological and ethical concerns about randomised trials have frequently occupied the medical literature as several clinical researchers feel uncomfortable with this kind of clinical research, especially when a placebo is allocated to patients with cancer, enlisted in a Phase III trial.
View Article and Find Full Text PDFGreater attention to flexible hospital designs and ventilated clinical facilities are a pre-requisite for coping with the next airborne pandemic.
Clin Microbiol Infect
October 2023
Department of Clinical Microbiology and Hygiene, Medilab, Academic Teaching Laboratories of the Paracelsus Medical University, Salzburg, Austria; ESCMID Study Group for Nosocomial Infections (ESGNI), Switzerland.
Interplay of pandemic and seasonal parameters in dental emergency service.
BMC Oral Health
November 2022
Department of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University, Augustusplatz 2, 55131, Mainz, Germany.
Background: To evaluate the relationship between pandemic events and dental emergency service frequentation. Utilization patterns in the scope of the COVID-19 pandemic were analyzed and considered in regard of seasonal parameters.
Methods: All outpatients seeking treatment in a university hospital's dental emergency service were analyzed in the years 2019, 2019 and 2020 according to demographic data and emergencies were subdivided into "absolute" and "relative".
Assessment of the Effectiveness of Omicron Transmission Mitigation Strategies for European Universities Using an Agent-Based Network Model.
Clin Infect Dis
December 2022
Graz University of Technology, Institute for Interactive Systems and Data Science, Graz, Austria.
Background: Returning universities to full on-campus operations while the coronavirus disease 2019 pandemic is ongoing has been a controversial discussion in many countries. The risk of large outbreaks in dense course settings is contrasted by the benefits of in-person teaching. Transmission risk depends on a range of parameters, such as vaccination coverage and efficacy, number of contacts, and adoption of nonpharmaceutical intervention measures.
View Article and Find Full Text PDFThe CO-VID D-Lemma: A Call for Action.
Nutrients
February 2022
Section Endocrinology, Diabetes, Nutrition and Weight Management, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA.
It is remarkable how an invisible, inanimate particle-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19)-that is hell-bent on reproducing itself was able to bring our modern civilization to its knees [...
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