Can we still rely on the World Health Organization? It has not openly opposed the greed of the major global pharmaceutical companies, and its director-general, Gro Harlem Brundtland, has deferred to them.
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Relationship between pharmacotherapy for major depressive disorder and healthcare utilisation in British Columbia, Canada: a retrospective population-based cohort.
BMJ Open
December 2024
Centre for Health Services and Policy Research, The University of British Columbia, Vancouver, British Columbia, Canada.
Objectives: To describe the population that meets the criteria for major depressive disorder (MDD) in British Columbia (BC), compare patterns of healthcare utilisation between those with MDD who are and are not prescribed pharmacotherapy, and assess these relationships in models that control for potential confounding variables.
Design: We used a population cross-sectional study design among a cohort of individuals living with MDD and examined the relationship between pharmacotherapy and healthcare utilisation between 2019 and 2020 using linked billing and administrative data.
Setting: This study identified individuals with MDD using a validated case definition of International Classification of Diseases (ICD) codes in BC, Canada.
Avoidable factors associated with maternal death from postpartum haemorrhage: a national Malawian surveillance study.
BMJ Glob Health
January 2025
Women's and Children's Health, University of Liverpool, Liverpool, UK.
Background: Despite strong evidence-based strategies for prevention and management, global efforts to reduce deaths from postpartum haemorrhage (PPH) have failed, and it remains the leading cause of maternal mortality. We conducted a detailed review of all maternal deaths from 33 facilities in Malawi to identify health system weaknesses leading to deaths from PPH.
Methods: Data were collected regarding every maternal death occurring across all district and central hospitals in Malawi.
Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium.
J Clin Invest
January 2025
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Article Synopsis
- IPF development involves a two-hit process: an initial vulnerability of the lung's epithelial cells followed by a second injury that triggers fibrotic changes.
- Genetic factors play a crucial role in the first hit, while ongoing damage disrupts normal cell function and activates fibroblasts, leading to lung fibrosis.
- Understanding IPF in terms of its stages may lead to new treatments that target these underlying causes, aiming for a shift from palliative care to potential cures for patients.
Preparation and characterization of natural microcapsules EYG (egg yolk granules) with OPO(1,3-dioleic acid-2-palmitic acid triglyceride): Unique application of EYG riches in low/high-density lipoproteins on OPO stability.
Int J Biol Macromol
December 2024
National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan 430070, China; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China. Electronic address:
Glycerol 1,3-dioleic acid, 2-palmitate (OPO) structural lipids are one of the important types of breast milk replacement lipids. Due to the presence of polyunsaturated fatty acids (PUFA) in the OPO structure, causing it to be extremely unstable. This study aimed to embed OPO through homogenization and spray drying based on egg yolk granules (EYG, riches in low/high-density lipoproteins) to prepare OPO natural microcap1sules.
View Article and Find Full Text PDFFactors Contributing to Uptake of Stillbirth Evaluations: A Qualitative Analysis.
BJOG
December 2024
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Article Synopsis
- - The study aimed to understand the beliefs and experiences of parents regarding stillbirth evaluation decisions, exploring factors influencing their choices.
- - Interviewing 19 parents who experienced stillbirth in the last 5 years revealed various reasons for consenting to or declining evaluations, with facilitators including a belief in science and concern for future pregnancies, while barriers included emotional distress and prior diagnoses.
- - The findings highlight the need for better decision support and training for medical providers to help parents navigate the challenges of stillbirth evaluations, potentially improving their experiences and reducing future regrets.
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