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Unlabelled: How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that ticks infected with either (causative agent of anaplasmosis) or (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR).
View Article and Find Full Text PDFImpacts of seasonality on mercury concentrations, polyunsaturated fatty acids, and stable isotopes: implications for the use of tetragnathid spiders as sentinels.
Environ Toxicol Chem
January 2025
Molecular Biosciences PhD Program, Middle Tennessee State University, Murfreesboro, TN, United States.
Riparian spiders are used in ecotoxicology as sentinels of bioavailable contaminants that are transferred from aquatic to terrestrial habitats via emergent aquatic insects. Spiders in the family Tetragnathidae are particularly of interest because a high proportion of their diet consists of emergent aquatic insects and their contaminant loads reflect the amount transferred through the food web to riparian predators. The transfer of contaminants can be determined through food web tracers such as stable isotopes and polyunsaturated fatty acids; however, it is unclear how contaminants and tracers vary over the course of a year.
View Article and Find Full Text PDFAnalysis of radiation oncology integration within general practitioners' daily patient care: a cross-sectional survey in Germany.
Strahlenther Onkol
January 2025
Department of Radiation Oncology, Klinikum rechts der Isar, School of Medicine and Health, Technical, University of Munich (TUM), Ismaninger Str. 22, 81675, Munich, Germany.
Purpose: General practitioners (GPs) play a crucial role in providing interdisciplinary care for radiation oncology patients. This study aims to understand the specific needs and challenges faced by general practitioners in Germany when treating oncology patients.
Methods: A comprehensive web-based questionnaire with 24 items was disseminated to GPs in Germany via email using survio.
Coralyne Targets the Catalytic Domain of MMP9: An In Silico and In Vitro Investigation.
Crit Rev Oncog
January 2025
GITAM.
Coralyne (COR) is a protoberberine-like isoquinoline alkaloid, and it is known for double-stranded (ds) DNA intercalation and topoisomerase inhibition. It can also sensitize cancer cells through various mechanisms. COR reduces the proliferation and migration of breast cancer cells by inhibiting the expression and activity of matrix metalloproteinase 9 (MMP9).
View Article and Find Full Text PDFTalimogene laherparepvec (T-VEC) as a treatment for melanoma: A systematic review.
J Oncol Pharm Pract
January 2025
Apollo Institute of Medical Sciences and Research Chittoor, Andhra Pradesh, India.
Background And Aims: Melanoma now presents an average risk of 1 in 50 in the Western world. Talimogene laherparepvec (T-VEC), an FDAapproved oncolytic virus derived from Herpes Simplex Virus type 1 (HSV-1), has proven effective in reducing morbidity and mortality from melanoma but causes adverse effects like chills, fever, exhaustion, and injection site discomfort. Research focuses on combining T-VEC with immune checkpoint inhibitors, such as pembrolizumab, to enhance its efficacy and broaden its application.
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