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Protective effects of spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development.
Front Pharmacol
August 2024
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Thymic atrophy marks the onset of immune aging, precipitating developmental anomalies in T cells. Numerous clinical and preclinical investigations have underscored the regulatory role of spores (GLS) in T cell development. However, the precise mechanisms underlying this regulation remain elusive.
View Article and Find Full Text PDFMarkers and makers of NKT17 cells.
Exp Mol Med
June 2023
Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Invariant natural killer T (iNKT) cells are thymus-generated innate-like αβ T cells that undergo terminal differentiation in the thymus. Such a developmental pathway differs from that of conventional αβ T cells, which are generated in the thymus but complete their functional maturation in peripheral tissues. Multiple subsets of iNKT cells have been described, among which IL-17-producing iNKT cells are commonly referred to as NKT17 cells.
View Article and Find Full Text PDFRegeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy.
Inflamm Regen
May 2023
Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d. iNKT cells express an invariant T cell receptor (TCR) encoded by Vα14 Jα18 in mice and Vα24 Jα18 in humans and are activated by recognizing glycolipid antigens, such as α-galactosylceramide (αGalCer), presented by CD1d. iNKT cells exhibit anti-tumor activity via their NK-like cytotoxicity and adjuvant activity.
View Article and Find Full Text PDFHelicobacter pylori extracts cholesterol from the host and converts it to its glycosides. We found that cholesteryl 6'-O-acyl α-glucoside (ChAcαG) produced by H. pylori is recognised by both invariant Vα14 NKT (iNKT) cells and a C-type lectin receptor Mincle (Clec4e).
View Article and Find Full Text PDFInvariant natural killer T cells minimally influence gut microbiota composition in mice.
Gut Microbes
August 2022
Department of Immunology, University of Toronto, Toronto, ON, Canada.
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic molecules within only minutes of activation. As such, iNKT cells can fuel or dampen inflammation in a context-dependent manner.
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