The addition of pentosan polysulphate sodium (NaPPS) to thrombogenic prothrombin complex concentrates (PCC) dose-dependently reduces or abolishes thrombus formation in rats in the stasis model acc. to Wessler. However, no reduction of thrombogenicity was found in PCC preparations manufactured in the presence of NaPPS.
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Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, United States.
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Department of Urology, Ewha Womans University College of Medicine, Seoul, Korea.
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Verana Health, San Francisco, CA, United States of America.
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Article Synopsis
- Moderate to severe interstitial cystitis (bladder pain syndrome) currently lacks effective long-term treatments, with pentosan polysulfate having limitations and potential side effects.
- A study involving 12 women aged 39-76 tested BPC-157, an unapproved peptide, via bladder injections to evaluate its safety and efficacy for interstitial cystitis.
- Results showed that 10 out of 12 patients experienced complete symptom resolution after one injection, while the remaining 2 reported significant improvement, marking the first positive report on BPC-157 for this condition.
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