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Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study.
Toxicol Mech Methods
January 2025
Environmental Carcinogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
During out-of-area military operations, the presence of carcinogenic and/or genotoxic agents has been reported, posing potential health risks to deployed soldiers. Military working dogs (MWDs), trained to detect explosives in the same environments as soldiers, could also serve as sentinel animals, providing valuable information on exposure to hazardous agents. These dogs can help identify environmental and potential adverse effects on their health and that of their handlers, possibly before relevant pathologies manifest.
View Article and Find Full Text PDFMill. Essential Oil: Analysis of In Vitro and In Vivo Genotoxic and Cytotoxic Potentials by Employing Three Cytogenetic Endpoints.
Molecules
December 2024
The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria.
The highly valued oil of Mill. (Rosaceae), widely used in high perfumery, cosmetics, and other spheres of human life, obliges us to know and study the safety profile of the product obtained from the water-steam distillation of fresh rose petals. The genotoxicity of the essential oil (EsO) has not been thoroughly studied despite its wide range of applications.
View Article and Find Full Text PDFRNA sensing induced by chromosome missegregation augments anti-tumor immunity.
Mol Cell
December 2024
Department of Cell Biology, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan. Electronic address:
Viral mimicry driven by endogenous double-stranded RNA (dsRNA) stimulates innate and adaptive immune responses. However, the mechanisms that regulate dsRNA-forming transcripts during cancer therapy remain unclear. Here, we demonstrate that dsRNA is significantly accumulated in cancer cells following pharmacologic induction of micronuclei, stimulating mitochondrial antiviral signaling (MAVS)-mediated dsRNA sensing in conjunction with the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway.
View Article and Find Full Text PDFSafety Assessment of Butyric Acid-Rich Triglyceride Oil: A Novel Palatable Formulation of Butyrate for the Pediatric Population.
J Appl Toxicol
November 2024
Nestlé Research, Lausanne, Switzerland.
A novel, palatable butyric acid-rich triglyceride oil has been developed and is available as a food supplement for adults in the United States and Canada. A program of safety studies was conducted with butyric acid-rich triglyceride oil for the pediatric population. The oil was tested in a microbial reverse mutation assay Ames Test OECD471 (Organisation for Economic Co-operation and Development) in which all bacterial strains showed negative responses over the complete dose range in two independently repeated experiments.
View Article and Find Full Text PDFAssessment of the Genotoxic Potential of Repeatedly Heated Cooking Oil In Wistar Rats.
Biochem Genet
November 2024
Department of Biotechnology, Maris Stella College, Vijayawada, Andhra Pradesh, 520008, India.
Article Synopsis
- Repeated heating of cooking oils, particularly sunflower oil, generates harmful substances called polycyclic aromatic hydrocarbons (PAHs) that can cause cancer.
- A study conducted on Wistar rats showed that consuming food cooked in oils heated multiple times resulted in significant DNA damage and increased genetic abnormalities in their blood and bone marrow.
- The findings suggest that dietary habits involving the use of repeatedly heated oils can lead to serious long-term health risks due to the genotoxic effects of PAHs and the free radicals they create.
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