Purpose: To investigate the influence of different curing methods used to achieve softstart polymerization on the marginal adaptation of a resin-based composite in Class V restoration.
Materials And Methods: Class V cavities, with the gingival wall located 1 mm below the cemento-enamel junction, were prepared on buccal and lingual surface of 80 extracted premolar teeth. The teeth were randomly divided into 8 groups of 10 teeth. The cavities were restored with a combination of resin-based composite (Z100) and adhesive (Single Bond) in different softstart-polymerization techniques or placement techniques. Softstart-polymerization obtained from either softstart mode (Elipar Highlight) or the modified methods using standard curing unit (Spectrum 900 and XL3000), bulk or incremental filling techniques were also used. After thermocycling between 5 degrees C and 55 degrees C for 500 cycles, the specimens were immersed in 2% methylene blue dye at 37 degrees C for 6 hours. Longitudinal sections of the specimens were scored for marginal dye penetration under the microscope. Kruskal-Wallis and Mann-Whitney tests were used for statistical analysis.
Results: There was no statistically significant difference of dye penetration among techniques at enamel or dentin margins (P > 0.05). Dye penetration observed at dentin margins was significantly higher than that observed at enamel margins (P < 0.05) except for the group restored with a combination of incremental technique and softstart-polymerization using Spectrum curing unit. There was no statistically significant difference of microleakage between buccal and lingual cavities at enamel or dentin margins (P > 0.05).
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Clin Oral Investig
January 2025
Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil.
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Photobiomodul Photomed Laser Surg
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Department of Preventive Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia.
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January 2025
Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, 530004, P. R. China.
Although classical fluorescent dyes feature advantages of high quantum yield, tunable "OFF-ON" fluorescence, and modifiable chemical structures, etc., their bio-applications in deep tissue remains challenging due to their excessively short emission wavelength (that may lead to superficial tissue penetration depth). Therefore, there is a pressing need for pushing the wavelength of classical dyes from visible region to NIR-II window.
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January 2025
Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun, 130021, PR China; State Key Laboratory of Supramolecular Structure and Materials, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun, 130012, PR China. Electronic address:
The kidney, vital for metabolic balance, faces risks of severe diseases if dysfunctional. The glomerular filtration barrier (GFB), crucial for blood filtration, disrupts in conditions like diabetic nephropathy or nephritides, resulting in proteinuria or even renal failure. Monitoring GFB integrity is essential for early diagnosis or prognostic monitoring.
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Research Unit on Computational Biology and Drug Design, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico.
Cell-penetrating peptides (CPPs) offer a unique and efficient mechanism for delivering therapeutic agents directly into cancer cells. These peptides can traverse cellular membranes, overcoming one of the critical barriers in drug delivery systems. In this review, we explore recent advancements in the application of CPPs for cancer treatment, focusing on mechanisms, delivery strategies, and clinical potential.
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