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Rapamycin inhibits tamoxifen-induced endometrial proliferation in vitro as a pilot approach for endometrial protection in breast cancer.
Sci Rep
January 2025
Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192/Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Tamoxifen, a common adjuvant therapy for hormone receptor-positive breast cancer, is associated with an increased risk of endometrial pathologies, such as hyperplasia, polyps, and carcinoma. This study investigates rapamycin, an mTOR inhibitor, as a potential novel strategy for preventing tamoxifen-induced endometrial proliferation. This in vitro study utilised endometrial stromal cells isolated from infertile women.
View Article and Find Full Text PDFMachine learning Nomogram for Predicting endometrial lesions after tamoxifen therapy in breast Cancer patients.
Sci Rep
January 2025
Department of Obstetrics and Gynecology, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
Objective Endometrial lesions are a frequent complication following breast cancer, and current diagnostic tools have limitations. This study aims to develop a machine learning-based nomogram model for predicting the early detection of endometrial lesions in patients. The model is designed to assess risk and facilitate individualized treatment strategies for premenopausal breast cancer patients.
View Article and Find Full Text PDFPostmenopausal Endometriosis: Clinical Insights and Imaging Considerations.
Radiographics
December 2024
From the Department of Radiology and Diagnostic Imaging, Chamié Imagem da Mulher, Rua Casa do Ator 1117, CJ 72, São Paulo, SP 04546-004, Brazil (L.P.C.); Department of Radiology, Mayo Clinic, Rochester, Minn (W.M.V.B., L.X., P.C.A.); Department of Radiology, Clínica Izabela Pires Franco, Belém, Para, Brazil (I.V.P.F.); Imaging Institute, Cleveland Clinic Foundation, Cleveland, Ohio (M.K.F.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S.S.B.); Department of Radiology, Stanford University, Palo Alto, Calif (P.J.); and Department of Radiology, Mayo Clinic, Phoenix, Ariz (S.W.Y.).
Endometriosis is a chronic systemic condition characterized by the presence of ectopic endometrial-like tissue outside of the uterus. It occurs most often in reproductive-aged patients and less frequently in postmenopausal women. In postmenopausal patients, endometriosis is more common in those undergoing hormone replacement therapy or taking tamoxifen.
View Article and Find Full Text PDFLobular carcinoma metastasis to endometrial polyps: Insights from a case report and literature analysis.
Int J Surg Case Rep
November 2024
Department of Gynecology-Obstetrics, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy of Rabat, University Mohammed V Rabat, Morocco.
Introduction And Importance: Endometrial polyps are rare sites of metastatic breast carcinoma. Such cases have mainly been reported in tamoxifen-related polyps.
Case Presentation: We describe the case of a 56-year-old woman with invasive lobular carcinoma who was experiencing vaginal bleeding.
Postmarketing adverse events of tamoxifen in male and female patients with breast cancer.
Int J Cancer
February 2025
Department of Pharmacy, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Tamoxifen (TAM), a selective estrogen receptor (ER) modulator, has received approval for use in patients with breast cancer (BC) exhibiting positive ER expression. Given the widespread clinical use of TAM, a comprehensive real-world study of its adverse events (AEs) is warranted. The database for analysis, sourced from the Food and Drug Administration Adverse Event Reporting System (FAERS), covers the period from the first quarter of 2014 to the third quarter of 2023.
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