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Vascular HIF2 Signaling Prevents Cardiomegaly, Alveolar Congestion, and Capillary Remodeling During Chronic Hypoxia.
Arterioscler Thromb Vasc Biol
January 2025
Metabolic and Immune Diseases Department, Biomedical Research Institute Sols-Morreale (IIBM), National Research Council (CSIC), Autonoma University of Madrid, Spain (T.A.-G., S.M.-T., R.C.-M., S.U.-B., S.M.-P.).
Background: Hypoxia is associated with the onset of cardiovascular diseases including cardiac hypertrophy and pulmonary hypertension. HIF2 (hypoxia-inducible factor 2) signaling in the endothelium mediates pulmonary arterial remodeling and subsequent elevation of the right ventricular systolic pressure during chronic hypoxia. Thus, novel therapeutic opportunities for pulmonary hypertension based on specific HIF2 inhibitors have been proposed.
View Article and Find Full Text PDFCardiacField: computational echocardiography for automated heart function estimation using two-dimensional echocardiography probes.
Eur Heart J Digit Health
January 2025
Department of Cardiovascular Surgery of Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Aims: Accurate heart function estimation is vital for detecting and monitoring cardiovascular diseases. While two-dimensional echocardiography (2DE) is widely accessible and used, it requires specialized training, is prone to inter-observer variability, and lacks comprehensive three-dimensional (3D) information. We introduce CardiacField, a computational echocardiography system using a 2DE probe for precise, automated left ventricular (LV) and right ventricular (RV) ejection fraction (EF) estimations, which is especially easy to use for non-cardiovascular healthcare practitioners.
View Article and Find Full Text PDFPreoperative pulmonary function is associated with left ventricular assist device outcomes.
Surg Pract Sci
June 2024
Baylor Scott and White, The Heart Hospital, 4708 Alliance Blvd, Suite 540, Plano, TX, United States.
Introduction: Although left ventricular assist device (LVAD) implantation is associated with improved survival in patients with end-stage heart failure, the impact of preoperative pulmonary function on short-term outcomes is unclear.
Methods: We conducted a retrospective review of all primary LVAD implants at a single institution. Common measures of preoperative pulmonary function were evaluated.
Misdiagnosis of a Massive Pulmonary Thromboembolism in A Patient With Dextrocardia and a Pacemaker.
Cureus
December 2024
Department of Cardiology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, IRN.
Pulmonary thromboembolism (PTE) is the third most common cause of acute cardiovascular disease, which can lead to high morbidity and mortality if left untreated. Anatomical and electrophysiological variations and obesity may complicate timely diagnosis and delay required management. While computed tomography pulmonary angiography (CTPA) remains the most accurate diagnostic tool, initial assessments using electrocardiography (ECG) or echocardiography can be helpful in early suspicion.
View Article and Find Full Text PDFCardiac Complications From Herbal Remedies.
Cureus
December 2024
Department of Cardiology, Maimonides Medical Center, New York, USA.
The safety of traditional Chinese medicine (TCM) herbal remedies, particularly when used with modern medications or in non-traditional dosages, requires careful consideration. We present a case of a 62-year-old male with pre-existing cardiovascular risk factors who developed tachycardia-induced cardiomyopathy (TIC) potentially linked to prolonged use of the TCM supplement "Tan Ke Jing." The supplement contains licorice root, caffeine, and apricot kernel, which have known cardiovascular effects.
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