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Challenges and strengths experienced by fetal alcohol spectrum disorder diagnostic clinics in Canada.
J Intellect Dev Disabil
September 2024
The Canada FASD Research Network, Vancouver, Canada.
Background: The Canadian fetal alcohol spectrum disorder (FASD) diagnostic guideline provides clinicians with the process and procedure to reach an accurate diagnosis. However, organisational structure, culture, and resource utilisation vary. The objectives of this study were to identify the key challenges and strengths of successful FASD diagnostic clinics.
View Article and Find Full Text PDFAn Australian online training and support program for caregivers of children and youth with Fetal Alcohol Spectrum Disorder: Families linking with families.
J Intellect Dev Disabil
June 2024
NOFASD, Perth, Australia.
Background: Australia has limited supports to help families where Fetal Alcohol Spectrum Disorder (FASD) impacts children and young people. National Organisation for Fetal Alcohol Spectrum Disorder Australia (NOFASD), in conjunction with the University of Otago, New Zealand, piloted and established a 7-week online program to assist caregivers to develop strategies and supports to help their families live well in a disabling society.
Method: The online program, Families Linking with Families (FLWF), was delivered to 88 caregivers.
Background: Fetal Alcohol Spectrum Disorders (FASD) describes a wide range of neurological defects and craniofacial malformations associated with prenatal ethanol exposure. While there is growing evidence for a genetic component to FASD, little is known of the cellular mechanisms underlying these ethanol-sensitive loci in facial development. Endoderm morphogenesis to form lateral protrusions called pouches is one key mechanism in facial development.
View Article and Find Full Text PDFArticle Synopsis
- Substance use disorders among pregnant and postpartum individuals are increasing, highlighting the need for better education and intervention for healthcare providers.
- The review covers the impact of various substances like nicotine, cannabis, and opioids on maternal and fetal health, along with treatment options.
- It also discusses ethical and legal issues related to substance use during pregnancy, advocating for equitable, non-stigmatizing care practices.
Paternal alcohol exposure affected offspring mesenteric artery via ROS-Cacna1c and DNA hypomethylation.
J Hypertens
December 2024
Institute for Fetology, The First Affiliated Hospital of Soochow University, Jiangsu.
Background: Paternal preconception alcohol exposure affects fetal development; however, it is largely unknown about the influences on offspring vasculature and mechanisms.
Methods: Offspring born form paternal rats treated with alcohol or water before pregnant was raised until 3 months of age. Vessel tone of mesenteric arteries was detected using myograph system; whole-cell calcium channel current in smooth muscle cells was tested using patch-clamp; molecule expressions were detected with real-time PCR, western blotting, and Dihydroethidium (DHE); DNA methylations were determined using targeted bisulfate sequencing assay.
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