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Evaluation of Polygenic Risk Score for Prediction of Childhood Onset and Severity of Asthma.
Int J Mol Sci
December 2024
Institute of Biochemistry and Genetics, Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, 450054 Ufa, Russia.
Asthma is a common complex disease with susceptibility defined through an interplay of genetic and environmental factors. Responsiveness to asthma treatment varies between individuals and is largely determined by genetic variability. The polygenic score (PGS) approach enables an individual risk of asthma and respective response to drug therapy.
View Article and Find Full Text PDFPre-diagnostic 25-hydroxyvitamin D levels and subsite-specific colorectal cancer risk: A nested case-control study from the Norwegian Women and Cancer Study (NOWAC).
Br J Nutr
January 2025
Department of Community Medicine, University of Tromsø - The Arctic University of Norway, 9037 Tromsø, Norway.
Colorectal cancer, the third most common cancer globally, causes over 900,000 deaths annually. Although vitamin D is observed to have potential anti-carcinogenic properties, research findings on its preventable effect against colorectal cancer remain inconclusive. Notably, different subsites within the colon and rectum may be associated with distinct risk factors.
View Article and Find Full Text PDFPopulation genomics advances in frontier ethnic minorities in China.
Sci China Life Sci
December 2024
Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, 200438, China.
China, with its large geographic span, possesses rich genetic diversity across vast frontier regions in addition to the Han Chinese majority. Importantly, demographic events and various natural and cultural environments in Chinese frontier regions have shaped the genomic diversity of ethnic minorities via local adaptations. Thus, insights into the genetic diversity and adaptive evolution of these under-represented ethnic groups are crucial for understanding evolutionary scenarios and biomedical implications in East Asian populations.
View Article and Find Full Text PDFPost-genomic illumination of paclitaxel biosynthesis.
Nat Plants
December 2024
Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Article Synopsis
- * Currently, paclitaxel is produced through a semi-synthesis process, using a compound called baccatin III extracted from Taxus plants, although many biosynthesis intermediates remain unknown.
- * Recent genomic studies have identified key genes for baccatin III and paclitaxel biosynthesis, which could lead to advancements in understanding the full biosynthetic pathway and improving industrial production through synthetic biology, despite ongoing significant challenges.
Article Synopsis
- Varicocele is a leading cause of male infertility, and while microsurgical varicocelectomy can improve sperm quality, many men with the condition are not infertile and spontaneous pregnancies post-surgery can vary significantly.
- Advances in proteomic analysis are being explored for diagnosing male infertility, focusing on seminal plasma proteins which play a crucial role in fertilization.
- The complexity of varicocele as a disease suggests that using post-genomic technologies could enhance understanding of the factors affecting sperm production and improve predictions of treatment success.
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