Objective: To assess the epidemiology of the primary systemic vasculitides (PSV) in a well-defined population of southern Europe over a 14-year period using the Chapel Hill Consensus Conference (CHCC) definitions.
Methods: The case records of all patients 15 years or older with vasculitis diagnosed between January 1988 and December 2001 at a single reference hospital in the Lugo region of northwest Spain were reviewed. Incidence rates were age- and sex-adjusted to the European standard population. Patients were classified as having PSV according to the CHCC definitions.
Results: Fifty-four Lugo residents (29 men) fulfilled the CHCC definitions for PSV. The mean age was 60.7 +/- 13.5 years (men: 61.0 +/- 13.4; women: 60.4 +/- 13.8 years). The overall annual incidence of PSV was 13.07/million (95% confidence interval [95% CI] 8.89-19.22). PSV were slightly more common in men. The age-specific incidence showed a clear increase with age. A peak in the 55-64 year age group for the whole group of patients with PSV was observed (34.9/million; 95% CI 28.6-42.6). Nonrandom periodical peaks of incidence every 3 years were only observed when the group of PSV was considered as a whole (P = 0.040). The annual incidence was 2.95/million (95% CI 1.44-6.05) for Wegener's granulomatosis (WG) and 7.91/million (95% CI 4.74-13.20) for microscopic polyangiitis (MPA) (P = 0.035). None of the patients with Churg Strauss syndrome (n = 4) lived in a rural area.
Conclusion: Our observations support an increasing incidence of PSV with age. In patients from northwest Spain defined by the CHCC definitions, MPA is more common than WG.
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http://dx.doi.org/10.1002/art.11115 | DOI Listing |
Mol Plant Pathol
December 2024
State Key Laboratory of Crop Stress Resistance and High-Efficiency Production, College of Agronomy, Northwest A&F University, Yangling, China.
Cytokinin signalling plays both positive and negative roles in plant resistance to pathogens. It is not clear whether the role of cytokinin changes at the different stages of pathogen infection. Arabidopsis thaliana sequentially exhibits distinct root morphological symptoms during Ralstonia solanacearum infection, which offers a good system to investigate function of cytokinin in the whole pathogen infection process.
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December 2024
Department of Oncology, University of Debrecen, Debrecen, Hungary.
Kidney Int
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Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to estimate the general-population prevalence of low eGFR internationally. Therefore, we estimated the age-standardized prevalence of eGFR under 60 ml/min per 1.73m in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and location.
View Article and Find Full Text PDFSci Total Environ
December 2024
Centro Oceanográfico de Vigo, Instituto Español de Oceanografía (IEO-CSIC), Vigo, Spain.
Harmful algal blooms (HABs) of toxin-producing microalgae are recurrent in Patagonian fjord systems. Like toxigenic HABs, high-biomass harmful algal blooms (HB-HABs) have important socio-economic repercussions, but most studies have focused on the former. Here we report the formation and development of an intense HB-HAB of Prorocentrum micans that occurred in Northwest Chilean Patagonia in the late summer (February-March) of 2022.
View Article and Find Full Text PDFPrev Vet Med
December 2024
School of Geography and Planning, Cardiff University, Cardiff, Wales CF10 3WA, United Kingdom. Electronic address:
This study explores the implementation of biosecurity measures by farm workers through daily work routines on dairy cattle farms in Spain. The implementation of biosecurity measures on dairy cattle farms is mainly decided by farmers and veterinarians, but it is carried out by both farmers and farm workers. However, farm workers may be affected by socio-employment factors such as the precariousness of their work such that implementation of biosecurity measures may be context dependent and may differ from official recommendations.
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