The effects of isoflavone on serum lipid and bone biochemical markers in ovariectomized rats were studied. Four-month old Wistar rats were divided into 6 groups according to their weights. Rats were either sham-operated or ovariectomized (ovx). Some ovx rats were given different dosage of isoflavone or estrostilben. Sixteen weeks later, the rats were killed and the serum were separated to determine the analytical indexes. The experiment results show that in the group of isoflavone the content of serum HDL and bone formation index bone gamma-carkoxyglutamate protein (BGP) increase, but total cholesterol (TC), triglycerides (TG) and bone absorption index tartrate-resistant acid phosphatase (TRAP) decrease obviously. The results from this study indicate that isoflavone can modulate serum lipid and inhibit bone absorption.
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