Limited deep tissue defects in the elbow area can occur after burns, advanced bursitis, and inflammatory processes, to name a few. Reconstruction is complicated because sufficient tissue with adequate elasticity and strength has to be transferred. Often major surgical procedures such as free tissue transfer are considered. A novel method for reconstruction of deep tissue defects in the elbow area, based on a single perforator artery and vein, is described. Perforator vessels are identified preoperatively using color Doppler ultrasonography, and a flap from the upper arm is rotated 180 degrees. The authors describe the successful treatment of two patients. The surgical technique is comparatively simple and can be performed with regional anesthesia. Postoperative recovery is short and skin sensibility is retained. The authors suggest that local, single perforator flaps can be considered as a first alternative in treatment of limited, deep tissue defects in the elbow area, especially for elderly or severely ill patients.
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http://dx.doi.org/10.1097/01.SAP.0000044144.48911.62 | DOI Listing |
Tech Coloproctol
January 2025
Peritonectomy and Liver Cancer Unit, Department of Surgery, St George Hospital, Kogarah, NSW, Australia.
Background: The goal of cytoreductive surgery for peritoneal malignancy is to remove all macroscopic disease, which occasionally requires the excision of the umbilicus. While the absence of the umbilicus can be aesthetically undesirable for patients, umbilical reconstruction is rarely performed due to the perceived complexity and increased risk of wound infections (Sakata et al. in Colorectal Dis 23:1153-1157, 2021).
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January 2025
Department of Computer Applications, Kalasalingam Academy of Research and Education - Deemed to be University, Krishnankoil, India.
Brain tumors can cause difficulties in normal brain function and are capable of developing in various regions of the brain. Malignant tumours can develop quickly, pass through neighboring tissues, and extend to further brain regions or the central nervous system. In contrast, healthy tumors typically develop slowly and do not invade surrounding tissues.
View Article and Find Full Text PDFSci Rep
January 2025
Melbourne Dental School, University of Melbourne, Level 5, 720 Swanston Street, Carlton, Melbourne, VIC, 3053, Australia.
Oral cancer detection is based on biopsy histopathology, however with digital microscopy imaging technology there is real potential for rapid multi-site imaging and simultaneous diagnostic analysis. Fifty-nine patients with oral mucosal abnormalities were imaged in vivo with a confocal laser endomicroscope using the contrast agents acriflavine and fluorescein for the detection of oral epithelial dysplasia and oral cancer. To analyse the 9168 images frames obtained, three tandem applied pre-trained Inception-V3 convolutional neural network (CNN) models were developed using transfer learning in the PyTorch framework.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.
Since clinical features of chronic muscle pain originating from the low back and limbs are different (higher prevalence and broader/duller sensation of low back muscle pain than limb muscle pain), spinal and/or supraspinal projection of nociceptive information could differ between the two muscles. We tested this hypothesis using c-Fos immunohistochemistry combined with retrograde-labeling of dorsal horn (DH) neurons projecting to ventrolateral periaqueductal grey (vlPAG) or ventral posterolateral nucleus of the thalamus (VPL) by fluorogold (FG) injections into the vlPAG or VPL. C-Fos expression in the DH was induced by injecting 5% formalin into the multifidus (MF, low back) or gastrocnemius-soleus (GS, limb) muscle.
View Article and Find Full Text PDFLight Sci Appl
January 2025
Department of Electrical and Computer Engineering, Boston University, Boston, MA, 02215, USA.
A major challenge in neuroscience is visualizing the structure of the human brain at different scales. Traditional histology reveals micro- and meso-scale brain features but suffers from staining variability, tissue damage, and distortion, which impedes accurate 3D reconstructions. The emerging label-free serial sectioning optical coherence tomography (S-OCT) technique offers uniform 3D imaging capability across samples but has poor histological interpretability despite its sensitivity to cortical features.
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