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Prevalence, management, health-care burden, and 90-day outcomes of prolonged mechanical ventilation in the paediatric intensive care unit (LongVentKids): an international, prospective, cross-sectional cohort study.
Lancet Child Adolesc Health
January 2025
CHU Sainte Justine Hospital, Montreal, QC, Canada.
Background: The number of children requiring prolonged mechanical ventilation (PMV) has increased with the advancement of medical care. We aimed to estimate the prevalence of PMV worldwide, document demographic and clinical characteristics of children requiring PMV in paediatric intensive care units (PICUs), and to understand variation in clinical practice and health-care burden.
Methods: This international, multicentre, cross-sectional cohort study screened participating PICUs in 28 countries for children aged >37 postgestational weeks to 17 years who had been receiving mechanical ventilation (MV; invasive or non-invasive) for at least 14 consecutive days.
Ceftobiprole Medocaril: A New Fifth-Generation Cephalosporin.
Ann Pharmacother
December 2024
Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Science, Wayne State University, Detroit, MI, USA.
Objective: The objective was to review the pharmacology, efficacy, and safety of intravenous ceftobiprole in the treatment of bloodstream infections, acute bacterial skin and skin structure infections (ABSSSIs), community-acquired pneumonia (CAP), and hospital-acquired pneumonia (HAP), or ventilator-associated pneumonia (VAP).
Data Sources: PubMed and ClinicalTrials.gov were searched using the following terms: ceftobiprole, ceftobiprole medocaril, ceftobiprole medocaril sodium, Zevtera, and BAL5788.
Duration of Antimicrobial Treatment in Adult Patients with Pneumonia: A Narrative Review.
Antibiotics (Basel)
November 2024
First Department of Critical Care Medicine and Pulmonary Services, School of Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece.
Pneumonia remains a major global health concern, causing significant morbidity and mortality among adults. This narrative review assesses the optimal duration of antimicrobial treatment in adults with community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP). Current evidence about the impact of treatment duration on clinical outcomes demonstrates that shorter antibiotic courses are non-inferior, regarding safety and efficacy, compared to longer courses, particularly in patients with mild to moderate CAP, which is in line with the recommendations of international guidelines.
View Article and Find Full Text PDFD-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care.
Crit Care
November 2024
Division of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Level 4, Addenbrooke's Hospital, Hills Road, Cambridge, UK.
Article Synopsis
- The D-PRISM study investigated global practices for diagnosing and treating pneumonia in ICU settings, focusing on community-acquired, hospital-acquired, and ventilator-associated pneumonia across different countries.
- A survey gathered responses from 1,296 ICU clinicians across 72 countries, revealing varied diagnostic processes and a lack of standardized microbiological testing, particularly in lower-income regions.
- Findings indicated that the typical antibiotic treatment duration was 5-7 days, with shorter durations linked to effective antimicrobial stewardship programs in higher-income countries.
How to prevent ventilator-associated pneumonia (VAP) in trauma patients.
Intensive Crit Care Nurs
February 2025
Department of Critical Care, King's College Hospital NHS Foundation Trust, London, United Kingdom; UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
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