[reaction: see text] A solid-phase method for the synthesis of tentoxin has been developed. Two key steps-dehydration and N-alkylation-are carried out while the peptide is anchored to the resin. The method, which has been validated by the preparation of a library of tentoxin analogues, should be applicable to the generation of further libraries that have the tentoxin scaffold structure, as well as other structures containing N-alkylated didehydroamino acids.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol0345273 | DOI Listing |
Publication Analysis
Top Keywords
tentoxin scaffold
8
synthesis tentoxin
8
tentoxin
5
scaffold drug
4
drug discovery
4
discovery total
4
total solid-phase
4
solid-phase synthesis
4
tentoxin library
4
library analogues
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!