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Magnolia kobus DC. suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model.
Chin Med
January 2025
Aging and Metabolism Research Group, Korea Food Research Institute, Wanju‑gun, 55365, Republic of Korea.
Background: Magnolia kobus DC (MO), as a plant medicine, has been reported to have various physiological activities, including neuroprotective, anti-inflammatory, and anti-diabetic effects. However, vascular protective effects of MO remain incompletely understood. In this study, we evaluated the vascular protective effect of MO against ferroptosis in a carotid artery ligation (CAL)-induced neointimal hyperplasia mouse model and in aortic thoracic smooth muscle A7r5 cells.
View Article and Find Full Text PDFBuilding a growing genomic repository for maternal and fetal health through the PING Consortium.
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Center for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.
Background: Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome.
View Article and Find Full Text PDFFramework for Site Specific Leachate Limits in MSW dumpsites: Integration of High-Resolution Site Characterization and Contaminant Transport Modeling.
Chemosphere
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Department of Civil Engineering, Indian Institute of Technology Delhi, New Delhi, Delhi, India, 110016. Electronic address:
The establishment of site-specific target limits (SSTLs) for old municipal solid waste (MSW) dumpsites is essential for defining remediation goals in a scientifically rigorous manner. However, a standardized framework for achieving this is currently lacking. This study proposes a comprehensive framework that integrates high-resolution site characterization (HRSC) tools, targeted sampling, and contaminant transport modeling to derive SSTLs.
View Article and Find Full Text PDFMiR8523 negatively regulates the immunity of Plutella xylostella against entomopathogenic fungus Isaria cicadae by targeting PxSpz5.
Int J Biol Macromol
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Anhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei 230036, China; Key Laboratory of Agri-products Quality and Biosafety (Anhui Agricultural University), Ministry of Education, Hefei 230036, China. Electronic address:
The diamondback moth, Plutella xylostella is a notorious pest and has developed serious resistance to insecticides. Entomopathogenic fungi (EPF) have been developed as eco-friendly alternatives to insecticides. Insects rely on their immunity to defend against fungi.
View Article and Find Full Text PDFEpithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosis.
EBioMedicine
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Department of Respiratory and Clinical Care Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. Electronic address:
Background: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with restrictive ventilation. Recently, the structural and functional defects of small airways have received attention in the early pathogenesis of IPF. This study aimed to elucidate the characteristics of small airway epithelial dysfunction in patients with IPF and explore novel therapeutic interventions to impede IPF progression by targeting the dysfunctional small airways.
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