AI Article Synopsis
- The study investigated the effects of a 10mg/kg aqueous extract of Spergularia purpurea (SP) on cholesterol and triglyceride levels, as well as body weight, in normal and diabetic rats.
- In normal rats, SP led to a significant reduction in plasma cholesterol after both single and repeated doses, while triglyceride levels initially increased but then decreased with repeated dosing.
- In diabetic rats, SP also significantly lowered cholesterol levels with both dosing methods and reduced triglycerides after repeated administration, but it caused a notable decrease in body weight in both normal and diabetic groups after two weeks.
Article Abstract
The purpose of this study was to examine the effect of single and repeated oral administration of the aqueous extract of Spergularia purpurea (SP) at a dose of 10mg/kg in normal and streptozotocin-induced diabetic rats. In normal rats, the aqueous extract of SP induced a significant decrease of the plasma cholesterol concentrations 6h after a single oral administration (P<0.05) and 2 weeks after repeated oral administration (P<0.05). The plasma triglycerides levels increased significantly 6h after a single oral administration (P<0.05) and decreased 2 weeks after repeated oral administration (P<0.05). In diabetic rats, SP treatment caused a significant decrease of plasma cholesterol levels after a single (P<0.01) and repeated (P<0.01) oral administration. A significant increase of triglycerides levels was observed 6h after a single oral administration of the SP aqueous extract (P<0.01). One week after repeated oral administration of SP aqueous extract, the plasma triglycerides levels were significantly decreased (P<0.005) and still dropped after 2 weeks (P<0.01). On the other hand, the repeated oral administration of SP aqueous extract caused a significant decrease of body weight after 2 weeks of treatment in both normal (P<0.001) and diabetic (P<0.01) rats. We conclude that the aqueous extract of SP exhibits a cholesterol and body weight-lowering activities in both normal and severe hyperglycaemic rats.
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| http://dx.doi.org/10.1016/s0378-8741(03)00102-8 | DOI Listing |
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