AI Article Synopsis
- Aspirin (ASA) was found to inhibit the growth of human hepatoma SKHep-1 cells in a time- and dose-dependent manner.
- An increase in intracellular hydrogen peroxide (H(2)O(2)) levels was detected as soon as 15 minutes after ASA treatment, which correlated with the induction of cell death (apoptosis).
- The presence of a catalase inhibitor enhanced the apoptotic effect of ASA on SKHep-1 cells, suggesting that H(2)O(2) plays a significant role in this process.
Article Abstract
Here we studied whether aspirin (ASA) has any influence on viability of human hepatoma-derived SKHep-1 cells and whether hydrogen peroxide (H(2)O(2)) has any relation with this effect. ASA inhibited SKHep-1 cell proliferation dose- and time-dependently. Intracellular H(2)O(2) increased as early as 15 min after ASA supplementation. Cellular apoptosis correlated with an increase in intracellular H(2)O(2) level. Moreover, in the presence of a catalase inhibitor-aminotriazol, ASA showed more apoptotic effect on SKHep-1 cells with increasing intracellular H(2)O(2) level. In conclusion, the present results shows that ASA induced SKHep-1 cell apoptosis has a relation with an early increase in intracellular H(2)O(2) level and catalase inhibitor synergizes to induce this process.
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| http://dx.doi.org/10.1016/s1386-6346(03)00003-2 | DOI Listing |
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