The epithelium of the host plays an important first line of defense against most human pathogens. Microbial factors have been identified that are involved in the destruction of the structures that maintain the integrity of the epithelium. The mechanisms used by several, selected bacteria for the disruption of epithelial cell-cell junctions are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s1286-4579(03)00089-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Plasma Bacterial Metabolites in Crohn's Disease Pathogenesis and Complications.
Nutrients
December 2024
Department of Gastroenterology and Hepatology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Background/objectives: Crohn's disease is known for being associated with an abnormal composition of the bacterial flora, dysbiosis and intestinal function disorders. Metabolites produced by gut microbiota play a pivotal role in the pathogenesis of CD, and the presence of unspecific extraintestinal manifestations.
Methods: The aim of this study was a determination of the level of bacterial metabolites in blood plasma in patients with Crohn's disease.
Antibiotic prophylaxis for patients undergoing dental care: a multi-centre evaluation in community and hospital dental services.
Br Dent J
January 2025
Consultant in Special Care Dentistry, Guy´s and St Thomas´ NHS Foundation Trust, London, UK.
Background Infective endocarditis (IE) is a life-threatening condition known to be associated with transient bacteraemia, the source of which can be the oral cavity. Scottish Dental Clinical Effectiveness Programme (SDCEP) 2018 implementation advice was introduced to provide practical guidance on National Institute for Health and Care Excellence Clinical Guideline 64 (2016) for management of patients at risk of IE undergoing dental treatment.Aims To assess current compliance with SDCEP's Antibiotic prophylaxis against infective endocarditis in six UK special care dentistry services.
View Article and Find Full Text PDFTimescale and genetic linkage explain the variable impact of defense systems on horizontal gene transfer.
Genome Res
January 2025
Centro de Astrobiología (CAB), CSIC-INTA, Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza
Prokaryotes have evolved a wide repertoire of defense systems to prevent invasion by mobile genetic elements (MGE). However, because MGE are vehicles for the exchange of beneficial accessory genes, defense systems could consequently impede rapid adaptation in microbial populations. Here, we study how defense systems impact horizontal gene transfer (HGT) in the short and long terms.
View Article and Find Full Text PDFCaveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation and Host-Pathogen Interaction.
Cells
December 2024
Molecular and Cellular Microbiology Laboratory, Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
Within mammalian cells, diverse endocytic mechanisms, including phagocytosis, pinocytosis, and receptor-mediated endocytosis, serve as gateways exploited by many bacterial pathogens and toxins. Among these, caveolae-mediated endocytosis is characterized by lipid-rich caveolae and dimeric caveolin proteins. Caveolae are specialized microdomains on cell surfaces that impact cell signaling.
View Article and Find Full Text PDFIn-cell NMR reveals metabolic adaptations in central carbon pathways driving antibiotic tolerance in Typhimurium.
Anal Methods
January 2025
Department of Health Technology, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark.
Antibiotic tolerance presents a significant challenge in eradicating bacterial infections, as tolerant strains can survive antibiotic treatment, contributing to the recurrence of infections and the development of resistance. However, unlike antibiotic resistance, tolerance is not detectable by standard susceptibility assays such as minimal inhibitory concentration (MIC) tests. Consequently, antibiotic tolerance often goes unnoticed in clinical settings.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!