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Childhood obesity poses a significant public health challenge, yet the molecular intricacies underlying its pathobiology remain elusive. Leveraging extensive multi-omics profiling (methylome, miRNome, transcriptome, proteins and metabolites) and a rich phenotypic characterization across two parts of Europe within the population-based Human Early Life Exposome project, we unravel the molecular landscape of childhood obesity and associated metabolic dysfunction. Our integrative analysis uncovers three clusters of children defined by specific multi-omics profiles, one of which characterized not only by higher adiposity but also by a high degree of metabolic complications.
View Article and Find Full Text PDFEmbedding Service User Experience ('Experts by Experience') Into Undergraduate Mental Health Nursing Education: A Co-Production Research Project.
Int J Ment Health Nurs
February 2025
University of Galway, Galway, Ireland.
Internationally, the need to have service user involvement (the 'voice' of recovery journeys) as an established and significant feature on the landscape of professional development has been widely discussed in the area of mental health nursing (MHN) education for over a decade. Service user involvement contributes to a different understanding, bringing 'new' ways of knowing in nursing education and potentially new ways of practicing within mental health services. The objective of this co-produced research was to investigate the current local 'state of play' of service user involvement in MHN student education in a regional university in the Republic of Ireland.
View Article and Find Full Text PDFYou cannot be what you cannot see: a retrospective natural longitudinal cohort study exploring the impact of face-to-face rural immersion on student medical training satisfaction and intention to practice rurally.
BMJ Open
January 2025
Rockhampton Regional Clinical Unit, Medical School, Faculty of Medicine, The University of Queensland, Rockhampton, Queensland, Australia.
Objective: Community-engaged immersive rural experiences were limited during the COVID-19 pandemic when online learning was instigated across medical institutions globally. This study aimed to explore the impact of online learning on medical students' satisfaction levels and intentions to practice in a rural area after graduation.
Design, Setting And Participants: We conducted a natural quasi-experimental longitudinal retrospective cross-sectional study during 2011-2022 for all Australian domestic medical students who undertook a Rural and Remote Medicine (RRM) placement at the University of Queensland.
Isolated fallopian tube torsion with hydrosalpinx in a 14 year old girl: A case report.
Int J Surg Case Rep
January 2025
Ranga Hospital, Coimbatore, India.
Introduction: Isolated fallopian tube torsion (IFTT) is an exceedingly rare but serious cause of acute abdominal pain, especially in pediatric patients, with a reported prevalence of 1 in 1.5 million women. It occurs when the fallopian tube twists around its own axis, leading to venous and lymphatic obstruction, ischemia, and potential necrosis, without involving the ipsilateral ovary.
View Article and Find Full Text PDFBrodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations.
Ecotoxicol Environ Saf
January 2025
Section IV 1.2 Biocides, German Environment Agency, Dessau-Roßlau 06813, Germany.
Widely used second-generation anticoagulant rodenticides like brodifacoum are classified as persistent, bioaccumulative, and toxic. Widespread exposure of terrestrial and avian non-target species is well-known and recently hepatic anticoagulant rodenticide residues have been detected in wild fish. However, no sufficient data exist to interpret the effects of these findings on fish health.
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