In rabbits, i. v. administration of 2,4-dinitrophenol (20 mg/kg) rapidly increases the temperature and the blood flow speed, simultaneously decreasing the oxygen available, in the skeletal muscle. The muscular and rectal temperatures go on raising up to the maximum till about 90th min and then slowly decrease. The blood flow speed starts rapidly to decrease after the 5th-6th min, while oxygen available starts to increase fradually by the end of the 1st hour. The data obtained are related to the mechanism of increase in the peripheral heat production.
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