AI Article Synopsis
- The study investigates how the mt5178 A/C polymorphism in mitochondrial DNA relates to longevity and age-related diseases among Japanese men.
- It specifically looks at how this genetic variation affects serum protein fraction levels in smokers compared to nonsmokers.
- Findings indicate that in men with the mt5178C genotype, smoking increases certain protein levels, while no significant difference is found in those with the mt5178A genotype, suggesting a genetic influence on smoking's impact on health.
Article Abstract
Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is reportedly associated with longevity and susceptibility to age-related diseases in Japanese individuals. We previously reported an association between mt5178 A/C polymorphism and serum protein fraction levels in healthy Japanese women. An association between habitual smoking and serum protein fraction levels has also been reported previously. The aim of this study was to examine whether mt5178 A/C polymorphism influenced the effects of habitual smoking on serum protein fraction levels in 321 healthy Japanese men. In mt5178C genotype men, alpha-1 and alpha-2 globulin levels were higher in smokers than in nonsmokers (P<0.001, and P=0.002, respectively). The influence of smoking on these globulin levels depended on cigarette consumption. However, in mt5178A genotype men, no significant difference was observed in alpha-1 or alpha-2 globulin levels between smokers and nonsmokers. These results suggest that longevity-associated mt5178 A/C polymorphism may influence the effects of cigarette smoking on serum protein fraction levels in healthy Japanese men.
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| http://dx.doi.org/10.1016/s0047-6374(03)00110-6 | DOI Listing |
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