Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(03)00328-7 | DOI Listing |
Publication Analysis
Top Keywords
neocarzinostatin chromophore
8
chemical synthesis
4
synthesis cytotoxicity
4
cytotoxicity dihydroxylated
4
dihydroxylated cyclopentenone
4
cyclopentenone analogues
4
analogues neocarzinostatin
4
chromophore compounds
4
compounds naphthoate
4
naphthoate moiety
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!