What governs the shape and size of a neuron's dendritic arbor? Part of the answer lies in the rules that govern interactions between dendrites. Interesting new insights into these rules have come from two recent studies on the embryonic sensory system of Drosophila.
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http://dx.doi.org/10.1016/s0960-9822(03)00361-0 | DOI Listing |
J Comp Neurol
January 2025
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Direction selectivity is a fundamental feature in the visual system. In the retina, direction selectivity is independently computed by ON and OFF circuits. However, the advantages of extracting directional information from these two independent circuits are unclear.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
A water extract of the Ayurvedic plant (L.) Urban, family Apiaceae (CAW), improves cognitive function in mouse models of aging and Alzheimer's disease and affects dendritic arborization, mitochondrial activity, and oxidative stress in mouse primary neurons. Triterpenes (TT) and caffeoylquinic acids (CQA) are constituents associated with these bioactivities of CAW, although little is known about how interactions between these compounds contribute to the plant's therapeutic benefit.
View Article and Find Full Text PDFFront Psychiatry
January 2025
Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany.
Background: The basolateral complex of the amygdala is a crucial neurobiological site for Pavlovian conditioning. Investigations into volumetric alterations of the basolateral amygdala in individuals with major depressive disorder (MDD) have yielded conflicting results. These may be reconciled in an inverted U-shape allostatic growth trajectory.
View Article and Find Full Text PDFCell Mol Life Sci
January 2025
School of Life Science and Technology, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China.
The selective elimination of inappropriate projections is essential for sculpting neural circuits during development. The class IV dendritic arborization (C4da) sensory neurons of Drosophila remodel the dendritic branches during metamorphosis. Glial cells in the central nervous system (CNS), are required for programmed axonal pruning of mushroom body (MB) γ neurons during metamorphosis in Drosophila.
View Article and Find Full Text PDFbioRxiv
January 2025
Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Mitochondrial ATP production and calcium buffering are critical for metabolic regulation and neurotransmission making the formation and maintenance of the mitochondrial network a critical component of neuronal health. Cortical pyramidal neurons contain compartment-specific mitochondrial morphologies that result from distinct axonal and dendritic mitochondrial fission and fusion profiles. We previously showed that axonal mitochondria are maintained at a small size as a result of high axonal mitochondrial fission factor (Mff) activity.
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