We performed a case-control study to evaluate the association between antibiotic use and Clostridium difficile-associated diarrhea (CDAD), matching for admission unit and time at risk for CDAD. A multivariable regression model showed that treatment with fluoroquinolones (odds ratio 12.7; 95% confidence interval 2.6 to 61.6) was the strongest risk factor for CDAD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000134PMC
http://dx.doi.org/10.3201/eid0906.020385DOI Listing

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