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Novel polyomavirus in the endangered garden dormouse Eliomys quercinus.
Virol J
November 2024
Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio al. 7, Vilnius, LT-10257, Lithuania.
Article Synopsis
- The garden dormouse's population in Europe has declined significantly due to factors like habitat loss, climate change, and potentially pathogen exposure.
- In a study involving 89 garden dormice from Germany, researchers tested kidney samples for polyomavirus DNA and checked for antibodies in their body fluids.
- A new polyomavirus related to other known polyomaviruses was identified, with a small percentage of dormice testing positive for the virus, suggesting that further research is needed to determine its significance and specificity to the garden dormouse.
Bio-characteristics, tissue expression of miR-375 in hypothalamic-pituitary-ovarian axis and its regulation in reproduction-related diseases.
Sci Rep
November 2024
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, Henan, China.
Article Synopsis
- The study focused on the expression of miRNA-375 in the hypothalamic-pituitary-gonadal axis of female Hu sheep, involving cloning its precursor sequence and comparing it to data in various species.
- It used real-time PCR to measure the levels of miR-375 in various tissues, finding that its expression was highest in the pineal gland compared to other reproductive and brain tissues.
- The research identified that miR-375 is connected to multiple biological processes and pathways, particularly the Hippo and Wnt pathways, suggesting it plays a key role in regulating sheep reproduction.
Longitudinal multiomic profiling and corticosteroid modulation of the immediate innate immune response to an adenovirus-vector vaccine.
Vaccine
November 2024
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Inocras Inc., San Diego 92121, CA, United States. Electronic address:
Among new vaccine technologies contributed to the control of the COVID-19 pandemic, ChAdOx1 nCoV-19, a chimpanzee adenovirus (ChAd)-vector vaccine expressing the SARS-CoV-2 spike protein, could be administered globally owing to its low production cost and lack of a requirement for frozen storage. Despite its benefits, most recipients have reported immediate inflammatory reactions after the initial dose vaccination. We comprehensively examined the immune landscape following ChAdOx1 nCoV-19 vaccination based on the single-cell transcriptomes of immune cells and epigenomic profiles of monocytes.
View Article and Find Full Text PDFThe World Health Organization declared the Coronavirus disease of 2019 (COVID-19) a public health emergency of international concern on 30 January 2020, and a pandemic on 11 March 2020. Vaccines have proven to be vital in the effort to control and possibly eventually eradicate this viral infection. There have been reports of thromboembolic events associated with the use of vaccine but from available information, no reported case of atypical Hemolytic Uremic syndrome (HUS) in a black male has been described.
View Article and Find Full Text PDFIdentification of cross reactive T cell responses in adenovirus based COVID 19 vaccines.
NPJ Vaccines
June 2024
Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
Vaccination has proven to be a valuable tool to combat SARS-CoV-2. However, reports of rare adverse reactions such as thrombosis/thrombocytopenia syndrome after ChAdOx1 nCoV-19 vaccination have caused scientific, public and media concern. ChAdOx1 was vectorised from the Y25 chimpanzee adenovirus, which was selected due to low human seroprevalence to circumvent pre-existing immunity.
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