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Chemical Characterization and Differential Lipid-Modulating Effects of Selected Plant Extracts from Côa Valley (Portugal) in a Cell Model for Liver Steatosis.
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Clinic Academic Center of Coimbra (CACC), Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal.
Background/objectives: Côa Valley, located in the northeast of Portugal, harbors more than 500 medicinal plant species. Among them, four species stand out due to their traditional uses: Desf. (hemorrhages, urethritis, hepatitis), L.
View Article and Find Full Text PDFResearch on the Aging Characteristics of Simulated Asphalt Within Pavement Structures in Natural Environments.
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College of Civil Engineering, Nanjing Forestry University, Nanjing 210037, China.
The global asphalt production growth rate exceeded 10% in the past decade, and over 90% of the world's road surfaces are generated from asphalt materials. Therefore, the issue of asphalt aging has been widely researched. In this study, the aging of asphalt thin films under various natural conditions was studied to prevent the distortion of indoor simulated aging and to prevent the extraction of asphalt samples from road surfaces from impacting the aged asphalt.
View Article and Find Full Text PDFA Study on the Impact of Temperature on the Anchoring Durability of Carbon-Fiber-Reinforced Polymer Cables.
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School of Civil & Environmental Engineering and Geography Science, Ningbo University, Ningbo 315211, China.
To improve the application of carbon-fiber-reinforced polymers (CFRPs) in civil engineering, the long-term durability of CFRP anchorage systems has become a critical issue. Temperature fluctuations can significantly impact the bond performance between CFRPs and the load transfer medium (LTM), making it essential to understand the effects of temperature on the durability of CFRP anchorages. Therefore, this study investigates the influence of temperature on the durability of CFRP anchorages through aging tests on 30 epoxy-filled CFRP-bonded anchorage specimens, followed by pull-out tests.
View Article and Find Full Text PDFWhole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NAD Depletion with Salvage Pathway Impairment.
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Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke 329-0498, Japan.
Tacrolimus (TAC)-induced chronic nephrotoxicity (TAC nephrotoxicity) is a serious issue for long-term graft survival in kidney transplantation. However, the pathophysiology of TAC nephrotoxicity remains unclear. In this study, we analyzed whole blood samples from mice that developed TAC nephrotoxicity in order to discover its mechanism.
View Article and Find Full Text PDFTherapeutic Potential of Herbal Medicines in Combating Particulate Matter (PM)-Induced Health Effects: Insights from Recent Studies.
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College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Particulate matter (PM), particularly fine (PM) and ultrafine (PM) particles, originates from both natural and anthropogenic sources, such as biomass burning and vehicle emissions. These particles contain harmful compounds that pose significant health risks. Upon inhalation, ingestion, or dermal contact, PM can penetrate biological systems, inducing oxidative stress, inflammation, and DNA damage, which contribute to a range of health complications.
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