The method of variation of constants is an important tool used to solve systems of ordinary differential equations, and was invented by Euler and Lagrange to solve a problem in orbital mechanics. This methodology assumes that certain "constants" associated with a homogeneous problem will vary in time in response to an external force. It also introduces one or more constraint equations. We show that these constraints can be generalized in analogy to gauge theories in physics, and that different constraints can offer conceptual advances and methodological benefits to the solution of the underlying problem. Examples are given from linear ordinary differential equation theory and from orbital mechanics. However, a slow driving force in the presence of multiple time scales contained in the underlying (homogeneous) problem nevertheless requires special care, and this has strong implications to the analytic and numerical solutions of problems ranging from celestial mechanics to molecular dynamics. (c) 2003 American Institute of Physics.
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Micromachines (Basel)
December 2024
Department of Applied Mechanics, Faculty of Civil Engineering, Vilnius Gediminas Technical University, LT-10223 Vilnius, Lithuania.
This paper presents the design, development, and investigation of a novel piezoelectric inertial motor whose target application is the low Earth orbit (LEO) temperature conditions. The motor utilizes the inertial stick-slip principle, driven by the first bending mode of three piezoelectric bimorph plates, and is compact and lightweight, with a total volume of 443 cm and a mass of 28.14 g.
View Article and Find Full Text PDFBioengineering (Basel)
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Applied Bioinformatics, German Cancer Research Center, Berliner Str. 41, 69120 Heidelberg, Germany.
Thyroid eye disease (TED) is a common extrathyroidal manifestation of hyperthyroidism, typically associated with Graves' disease (GD). This condition can cause severe functional limitations as well as significant aesthetic concerns. Treatment for TED patients aims to restore functionality and address aesthetic concerns.
View Article and Find Full Text PDFArch Pharm (Weinheim)
January 2025
Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Sesto Fiorentino, Firenze, Italy.
2,2'-Thio-bis(4,6-dichlorophenol), namely bithionol, is a small molecule endowed with a multifaceted bioactivity. Its peculiar polychlorinated phenolic structure makes it a suitable candidate to explore its potentialities in establishing interaction patterns with enzymes of MedChem interest, such as the human carbonic anhydrase (hCA) metalloenzymes. Herein, bithionol was tested on a panel of specific hCAs through the stopped-flow technique, showing a promising micromolar inhibitory activity for the hCA II isoform.
View Article and Find Full Text PDFJ Phys Condens Matter
January 2025
School of Materials Science, Indian Association for the Cultivation of Science, Calcutta 700 032, Kolkata, West Bengal, 700032, INDIA.
An exotic quantum mechanical ground state, i.e. the nonmagnetic= 0 state, has been predicted for higher transition metal tsystems, due to the influence of strong spin-orbit coupling (SOC) or in other words, due to unquenched orbital moment contribution.
View Article and Find Full Text PDFPlast Reconstr Surg
January 2025
University of California Irvine and University of California Davis The Aesthetic Centers 3701 Birch St Ste 200, Newport Beach, CA 92660 · Email:
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