AI Article Synopsis
- The study aimed to assess how different crushing technologies affect the quality of Pills of Six Herbs with Rehmunnia, using Paeonol as a test marker for dissolution.
- Pills were prepared with either normal or super fine crushing techniques, and dissolution rates were measured using the rotatory-basket method and UV analysis.
- Results showed a significant difference in the dissolution rate (T50) of super fine crushed pills compared to normally crushed ones, indicating that super fine crushing enhances drug quality.
Article Abstract
Objective: To evaluate the affection of crushing technology on quality. The dissolution of Pills of Six Herbs with Rehmunnia prepared by different crushing technology was determined by taking the dissolution of Paeonol as test marker.
Method: The Pills was prepared with the fine powder which was crushed by normal crusher or super fine crusher. The rotatory-basket method was used, and the cumulative dissolution percentage was determined by UV.
Result: Statistics indicated there was a significant difference in dissolution parameter (T50) between super fine crushing powder Pills and normal fine-crushing powder Pills (P < 0.01), and there was a difference in dissolution of different batches of Pills of Six Herbs with Rehmunnia prepared by the normal crush technique (P < 0.05).
Conclusion: The determination of dissolution of Pills of Six Herbs with Rehmunnia is necessary. In order to improve the quality of drugs, we should adopt the technique of super fine crushing in the preparation procedure.
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