AI Article Synopsis
- The study investigated how an aqueous extract of detoxified cottonseeds (CTN-W) affects brain signaling.
- CTN-W was found to activate adenylyl cyclase (AC) in a dose-dependent way, indicating its potential role in enhancing brain chemistry.
- The extract also showed protective effects on PC12 cells against damage from corticosterone, suggesting its potential as an antidepressant and anxiolytic by activating the AC-cAMP signaling pathway.
Article Abstract
Objective: To study the possible mechanism of aqueous extract of detoxified cottonseeds (CTN-W).
Method And Result: CTN-W 0.01, 0.03, 0.10, 0.30 mg.mL-1 was incubated directly with the synaptic membrane extracted from the cerebral cortex in rats, and adenylyl cyclase (AC) activity was detected by using radio-immunoassay.
Result: Showed that CTN-W could activate AC in a dose-dependend manner. After incubation with PC12 cells in the presence of corticosterone 2 x 10(-4)mol.L-1 for 48 h, CTN-W 0.08, 0.4, 2 mg.mL-1 protected PC12 cells from the lesion induced by corticosterone.
Conclusion: Antidepressant and anxiolytic effects of CTN-W are related with the activation of AC-cAMP pathway in signal transduction system, thus protecting neurons from the lesion. These two aspects maybe partly form the mechanism of CTN-W's action.
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