AI Article Synopsis
- A study of 63 patients with fibrocavernous pulmonary tuberculosis assessed the effects of preoperative antituberculosis therapy on clinical and X-ray disease severity.
- The researchers compared changes in disease severity with various biochemical indices, including proteins related to inflammation and detoxification.
- Results indicated that improvement in clinical and X-ray characteristics could be predicted with 83% accuracy using baseline levels of albumin and ceruloplasmin, while other biomarkers did not improve prediction accuracy.
Article Abstract
Sixty-three patients with fibrocavernous pulmonary tuberculosis were examined before and 1 month after preoperative therapy with antituberculosis agents. The time course of changes in the clinical and X-ray characteristics of the severity of the disease were compared with the alterations of different biochemical indices, including acute-phase proteins, proteolysis inhibitors, intoxication severity. It was demonstrated that improvement of clinical and X-ray characteristics of the severity of a process after preoperative preparation could be predicted with an accuracy of 83% from the baseline serum concentrations of albumin and ceruloplasmin. The accuracy of prediction does not increase when the levels of protease inhibitors, C-reactive protein, adenosine deaminase, medium-weight molecules are simultaneously studied. The likelihood of the clinical and X-ray characteristics becoming better is higher with enhanced ceruloplasmin activity and decreased albumin levels.
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