AI Article Synopsis
- The study examined how Jiangzhining decoction affects the expression of liver LDLR (Low-Density Lipoprotein Receptor) in hyperlipemic rats.
- The experiment involved male Wister rats fed a high-fat diet and treated with the decoction for 15 days, followed by analysis of liver RNA to compare LDLR mRNA levels.
- Results showed that the decoction significantly raised LDLR expression compared to the hyperlipemic group, suggesting its potential in preventing and treating cardiovascular diseases related to high fat intake.
Article Abstract
Objective: To study the influence of Jiangzhining decoction on the genetic expression of Liver LDLR of the rats suffered from hyperlipemia.
Method: Laboratory animals were male wister rats with hyperlipemia resulting from high fat feeding. Prescription was the douche of stomach with Jiangzhining decoction (200%) with a dosage of 1.4 g.kg-1, for 15 successive days. Total RNA was extracted from the liver tissue of treated rats and LDLRmRNA was detected by Dot blot hybridization. Expression levels of LDLRmRNA was estimated by a ratio of LDLRmRNA and beta-actin mRNA.
Result: The difference between expression levels of LDLRmRNA for normal group and those for hyperlipemia group (100% +/- 19% vs 39% +/- 14%) was significant (P < 0.05); and the difference between decoction group (108 +/- 8%) and hyperlipimia group was also highly significant (P < 0.01).
Conclusion: High fat feeding reduces the expression of liver LDLRmRNA while the decoction can greatly increase it. The study and development of Jiangzhining are significant in preventing and curing cadiocerebral diseases.
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