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The Role of Chitinase 3-Like-1 (YKL-40) and Proinflammatory Biomarkers in the Pathogenesis of Pediatric Tick-Borne Encephalitis in a Polish Cohort.
J Inflamm Res
December 2024
Department of Pediatric Infectious Diseases, Medical University of Bialystok, Bialystok, Poland.
Background: Chitinase 3-like-1 (CHI3L1), also known as YKL-40, is a potential biomarker for neuroinflammatory conditions. It is upregulated in Alzheimer's disease, multiple sclerosis, and traumatic brain injury. However, its involvement in pediatric tick-borne encephalitis (TBE) has not been addressed yet.
View Article and Find Full Text PDFAnalysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development.
Viruses
October 2024
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Powassan virus (POWV) is an emerging tick-borne virus that causes severe meningoencephalitis in the United States, Canada, and Russia. Serology is generally the preferred diagnostic modality, but PCR on cerebrospinal fluid, blood, or urine has an important role, particularly in immunocompromised patients who are unable to mount a serologic response. Although the perceived poor sensitivity of PCR in the general population may be due to the biology of infection and health-seeking behavior (with short viremic periods that end before hospital presentation), limitations in assay design may also contribute.
View Article and Find Full Text PDFSpectrum and Evolution of Movement Disorder Phenomenology in a Pediatric Powassan Encephalitis Case Series.
Mov Disord Clin Pract
December 2024
Movement Disorders Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- * Three pediatric cases illustrate various movement disorders, such as myoclonus, dystonia, and dyskinesias, highlighting the complexity of the symptoms associated with Powassan encephalitis.
- * These movement disorders significantly impact the patients' health, emphasizing the need for ongoing monitoring and flexible treatment options, and indicating that more research is needed to understand these conditions better.
Effects of steroids on super-refractory status epilepticus in tick-borne meningoencephalitis.
Epilepsy Behav Rep
September 2024
Institute for Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland.
We report a unique case of super-refractory status epilepticus (SRSE) secondary to tick-borne encephalitis (TBE) to evaluate the therapeutic challenges and potential benefits of steroid treatment in this context. A previously healthy 31-year-old woman was admitted to the hospital with fever, headache, vertigo, and meningismus, ultimately diagnosed with TBE. Despite empirical antimicrobial treatment, the patient's condition deteriorated, leading to coma and SRSE.
View Article and Find Full Text PDFMeningitis and encephalitis in Poland in 2022.
Przegl Epidemiol
September 2024
Zakład Epidemiologii Chorób Zakaźnych i Nadzoru, Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny w Warszawie, Polska.
Article Synopsis
- * In 2022, Poland experienced a significant surge in cases, with 1,747 instances of meningitis and/or encephalitis reported, marking a 79.4% increase from the previous year, alongside notable rises in both bacterial and viral infections.
- * The analysis highlighted that viral infections made up 52% of the total cases, led by a dramatic increase in tick-borne encephalitis
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