AI Article Synopsis
- In a study, scientists looked at two types of mice: normal ones (WT) and ones genetically altered to lack a specific enzyme called 5-LO (KO).
- They found that the KO mice had less inflammation in their lungs when treated with a substance called carrageenan compared to the WT mice.
- The results indicated that the enzyme 5-LO plays a key role in controlling how many immune cells (neutrophils) move into the lungs during inflammation.
Article Abstract
In the present study, by comparing the responses in wild-type (WT) mice and mice lacking [knockout (KO)] the 5-lipoxygenase (5-LO), we investigated the role played by 5-LO in the development of acute inflammation. When compared with carragenan-treated 5-LOWT mice, 5-LOKO mice, which had received carrageenan, exhibited a reduced degree of pleural exudation, polymorphonuclear cell migration. Lung myeloperoxidase activity, an index of neutrophil infiltration, was significantly reduced in 5-LOKO mice in comparison with 5-LOWT. Lung-tissue sections from carrageenan-treated 5-LOWT mice showed positive staining for intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin, which were mainly localized around vessels. The intensity and degree of ICAM-1, VCAM-1, P-selectin, and E-selectin were markedly reduced in tissue section from carrageenan-5-LOKO mice, which also improved the histological status of the inflamed lungs. Taken together, our results clearly demonstrate that 5-LO modulates neutrophil infiltration in the acute lung inflammation.
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| http://dx.doi.org/10.1189/jlb.1002477 | DOI Listing |
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