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Anti-Müllerian hormone signaling in the ovary involves stromal fibroblasts: a study in humans and mice provides novel insights into the role of ovarian stroma.
Hum Reprod
November 2024
Fertility Preservation Laboratory, Sheba Medical Center, Tel Hashomer, Israel.
Study Question: What is the involvement of ovarian stroma in the anti-Müllerian hormone (AMH) signaling pathway and which stromal cells are involved?
Summary Answer: Mouse and human ovaries show high expression of AMH receptor II (AMHR2) in the stromal fibroblasts surrounding the follicles and activation of the post-AMHR2 pathway by recombinant AMH was evidenced by increased phosphorylation of SMAD1,5 and 9, increased expression AMHR2 and upregulation of αSMA, suggesting fibroblast activation to initiate myofibroblast differentiation.
What Is Known Already: AMH secreted by small growing follicles, regulates ovarian activity. It suppresses initial primordial follicle (PMF) recruitment and FSH-dependent growth.
The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-β-Responsive Colon Carcinoma.
J Cell Physiol
December 2015
Scientific Directorate, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Loss of response to TGF-β is a central event in the genesis of colorectal cancer (CRC), a disease that, in the majority cases, is refractory to growth inhibition induced by this cytokine. However, inactivating mutations at receptors and transducers from the TGF-β cascade occur only in approximately half of CRCs, suggesting the involvement of additional mechanisms altering the response to the cytokine. We have recently described the amplification of the 13q31 locus, where the miR-17-92 cluster maps, associated with overexpression of its members.
View Article and Find Full Text PDF20-Hydroxyecdysone attenuates TGF-β1-induced renal cellular fibrosis in proximal tubule cells.
J Diabetes Complications
April 2013
Department of Graduate Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan.
Unlabelled: Renal fibrosis progresses to end stage of diabetes kidney disease, which causes irreversible progressive proximal tubular injury. In a previous study, 20-hydroxyecdysterone (20-HE), a phytoecdysteroid, attenuated renal injury in diabetes models. However, the fibrosis regulatory role remains to be investigated.
View Article and Find Full Text PDF[Smad 7 and post-receptor signal regulation of transforming growth factor-beta1].
Zhonghua Gan Zang Bing Za Zhi
May 2003
Department of Gastroenterology, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China.
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